They're a class of painkillers known as non-steroidal anti-inflammatories (NSAIDs) and we take them to relieve a wide range of conditions from headaches and period cramps to arthritis. Recent research linking them with an increased risk of stroke received widespread publicity. Since most of us take these medicines at some time or another, how worried do we need to be? In Australia, NSAIDs include both prescription and over-the-counter medicines, such as: The research highlighting stroke risk was done in Denmark (where NSAIDs are available exclusively on prescription) and covered all of these NSAID types. It looked at about 450,000 people (median age 39) who had filled at least one prescription for a NSAID over a nine-year period. It found all the anti-inflammatory types were associated with an increased risk of fatal or nonfatal stroke, but different medicines carried different levels of risk. 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