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    Most cold sores heal on their own without prescription medicines. But some antiviral medicines (such as acyclovir or famciclovir) when taken orally (tablets) may be helpful in reducing the frequency and severity of attacks of . Doctors may prescribe oral antiviral medicines that can be taken daily to prevent future outbreaks of cold sores. These medicines may also be given during periods of increased risk of getting cold sores (such as during cosmetic surgery or sun exposure). Oral antivirals work best in treating recurring cold sores if they are taken within 24 to 48 hours of an outbreak of cold sores. Pregnant or nursing women should seek their doctors' advice prior to taking antiviral medicines. Those with kidney problems may be advised to take lower doses. Many people report that L-lysine, an amino acid, works quite well at preventing or shortening a cold sore outbreak. Not everyone has success with this approach, however. Sometimes a prescription drug is the solution to frequent or very painful outbreaks as this reader discovered. I had cold sores for 30 years before I found a solution. You recently mentioned L-lysine, but it didn’t work for me. Summer sunburns, icy cold winters and a stressful job all brought cold sores on frequently. Many dermatologists over the years prescribed things that did not work. When I complained to my internist, he said you need Valtrex.

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