Adding a common antibiotic to the usual daily treatment regimen for chronic obstructive pulmonary disease (COPD) can reduce the occurrence of acute exacerbations and improve quality of life, reports new results from a clinical trial funded by the National Heart, Lung, and Blood Institute (NHLBI), part of the National Institutes of Health. Previous research suggested that this antibiotic might work for COPD exacerbations, but this study was the first to enroll a large number of COPD patients and treat exacerbations with this drug over a long time. “Acute exacerbations account for a significant part of COPD’s health burden,” said Susan B. Azithromycin is already prescribed for a wide variety of bacterial infections including pneumonia and strep throat. “These promising results with azithromycin may help us reduce that burden and improve the lives of patients at risk.” COPD exacerbations are sudden onsets of worsened cough, wheeze, and labored breathing which are typically induced by bacterial and/or viral infection. Participants had a history of exacerbations in the previous year or needed oxygen therapy. The 570 study participants who took 250 milligrams of azithromycin daily for a year in addition to their usual care averaged 1.48 acute COPD exacerbations annually, compared to 1.83 exacerbations for the 572 participants who received their usual care without azithromycin. The participants taking azithromycin also assessed their own breathing ability and overall well-being more favorably on questionnaires. Eighty percent of the study participants were already taking other medications normally used to manage COPD, including inhaled steroids and long-acting bronchodilators. how to buy generic accutane The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Azithromycin, an antibiotic, may be beneficial at reducing the symptoms and severity of the disease. Listing a study does not mean it has been evaluated by the U. This study will analyze previously collected study data to evaluate the anti-inflammatory properties of azithromycin and determine how azithromycin affects the frequency and severity of COPD exacerbations. Chronic obstructive pulmonary disease (COPD) is a chronic lung disease. COPD is a disease in which the lung airways are partly damaged and obstructed, making it difficult to breathe. The most common cause is cigarette smoking, but breathing in other types of lung irritants, including pollution, dust, and chemicals, over a long period of time may also contribute to COPD. It is the fourth leading cause of death in the United States. Symptoms include coughing, excess mucus production, shortness of breath, wheezing, and chest tightness. Where to buy cialis in phnom penh Clomid pregnancy rates Long-term continuous cyclic azithromycin therapy for severe chronic obstructive pulmonary disease was associated with reductions in exacerbations and hospitalizations. dapoxetine 60 mg tablets Long-term azithromycin therapy has been shown to reduce exacerbations of. KEYWORDS Azithromycin; COPD exacerbation; Macrolide; QT prolongation. Long-term azithromycin therapy has been shown to reduce exacerbations of chronic obstructive pulmonary disease COPD, and is recommended by recent society guidelines. Exacerbations of chronic obstructive pulmonary disease contribute to the high mortality rate associated with the disease. Randomized controlled trials have demonstrated the effectiveness of multiple interventions. The first step in outpatient management should be to increase the dosage of inhaled short-acting bronchodilators. Combining ipratropium and albuterol is beneficial in relieving dyspnea. Oral corticosteroids are likely beneficial, especially for patients with purulent sputum. The use of antibiotics reduces the risk of treatment failure and mortality in moderately or severely ill patients. Physicians should consider antibiotics for patients with purulent sputum and for patients who have inadequate symptom relief with bronchodilators and corticosteroids. Your order will be packed safe and secure and dispatched within 24 hours. This is exactly how your parcel will look like (pictures of a real shipping item). 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