Welcome to HW....our lil family From what others have posted YES it can cause extreme fatigue or go the other way make you hyper...takes OR can take up to 4 to 6 weeks for this med to totally kick in and start to work .......... Are you on a benzo like Xanax or valium,ativan ect as well or just the zoloft???????? I am sure glad you found us here at HW and hoping that you do see the caring and support there is here ....... Go to Resources in yellow at side as well you can read on some back pages other threads about this or anything else you may want to know If not then start another thread ........you did here asking your questions.......... LYN **BTW** there are many self help techniques to learn and they do help you get theu this along with the meds such as Relaxation........ Cognitive behavioural Therapy ( free online one) and others I am sure ppl will post to help you lout Like I said this is a family and the support is fantastic as are the ppl.......... You have found a great place to gain advice on a lot of different issues/topics. I used to be on Zoloft and when I first started it, I was very tired, but eventually it did subside. Again, a warm welcome to the HW family and keep us posted on how things are going for you. Wen Co-Moderator Anxiety/Panic Disorders Evey little bit helps, please donate if you can! https:// Dx: Agoraphobia, Anxiety/Panic Disorders, Barrett's Esophagus, Bipolar Disorder, Depression, Fibromyalgia, I. S., Mitral Valve Prolapse, Narcolepsy, PTSD, Restless Leg Syndrome, Severe Acid Reflux, Sleep Apnea, Social Anxiety Rx: Abilify, Ambien CR, Ativan , Flexeril, Lamictal, Neurontin, Nexium, Requip, Ritalin ER, Valium Always bear in mind that your own resolution to succeed is more important than any other one thing. 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