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The warning indicated that some people may have an increased risk of sudden death when taking this drug, especially people with certain kinds of heart disease. The FDA warning led to widespread media coverage, and given the popularity of the Z-Pack (which is prescribed an estimated 60 million times per year), it also led to widespread fear and consternation among patients and physicians alike. And in certain individuals — those who are born with a variant of the long QT syndrome, which is a genetic condition that can produce cardiac arrhythmias — anything that prolongs the QT interval can increase the risk of a dangerous arrhythmia called ventricular tachycardia. Azithromycin thus joins a long list of drugs that can prolong the QT interval, and which can, therefore, increase the risk of sudden death in susceptible individuals who have a variant of long-QT syndrome or heart disease. These drugs, in addition to antibiotics, include several antiarrhythmic medications (drugs that, ironically, are supposed to prevent arrhythmias), several antidepressant drugs, and several drugs used for gastrointestinal symptoms. There is no reason to think that azithromycin is any more dangerous than any of the other drugs on this lengthy list: that is, for people with a variant of the long QT syndrome or various kinds of heart disease, any of these drugs can be potentially dangerous. For anyone else, these drugs apparently can be taken without worrying about the arrhythmias associated with a long-QT interval. 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Zithromax (azithromycin), also known as Z-Pak, is an antibiotic approved for treatment of respiratory, skin and other bacterial infections. Food and Drug Administration warned of an increased risk of cancer relapse and death in some patients who take the drug long-term. Studies link the drug to side effects, including an increased risk of fatal heart problems. Board-certified physicians medically review Drugwatch content to ensure its accuracy and quality. Drugwatch partners with Physicians’ Review Network Inc. PRN is a nationally recognized leader in providing independent medical reviews. Reviewer specialties include internal medicine, gastroenterology, oncology, orthopedic surgery and psychiatry. Azithromycin is used to treat a wide variety of bacterial infections. Unnecessary use or misuse of any antibiotic can lead to its decreased effectiveness. This medication will not work for viral infections (such as common cold, flu). 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