If you suffer from anxiety, panic disorder or insomnia, your doctor may have prescribed you a tranquilizer belonging to a class of drugs known as benzodiazepines. Drugs such as Xanax (alprazolam), Valium (diazepam), Ativan (lorazepam), and Klonopin (clonazepam) are some of the most-prescribed medicines – more than 133.4 million such prescriptions were filled in the US in 2014. As with any medication, drug interactions can occur if you take a benzo with another medication, and in certain cases, may be life-threatening. The first is that interactions might increase the effects of the drug, which can result in oversedation, accidents and/or overdose. The second is that interactions could decrease the amount of a benzo in the bloodstream of a patient who has been on the drug for a long time, which can result in withdrawal symptoms, the most severe being seizures and death. Here are 4 drug classes that can have dangerous interactions with benzodiazepines. Opioids: 1: any of a group of endogenous neural polypeptides (as an endorphin or enkephalin) that bind especially to opiate receptors and mimic some of the pharmacological properties of opiates—called also opioid peptide 2: a synthetic drug (as methadone) possessing narcotic properties similar to opiates but not derived from opium. Via Medline Plus " class="glossary Link " such as Oxy Contin (oxycodone), morphine, and Vicodin (hydrocodone) are painkillers. fluconazole for candidiasis Immediate-release: Decrease initial dose to 0.25 mg PO q8-12hr; may gradually increase if necessary and as tolerated; may increase every 3-4 days by ≤1 mg/day to 5-6 mg/day average dose Extended-release: Start at 0.5 mg PO q Day; may gradually increase if necessary and as tolerated; may increase q3-4Days by ≤1 mg/day to 3-6 mg/day Use smallest effective dose to avoid ataxia and oversedation Elderly especially sensitive to benzodiazepine effects; higher plasma levels exhibited because of reduced clearance Mean half-life: 16.3 hours in healthy elderly individuals (range: 9-26.9 hr), compared with 11 hours in healthy adults (range: 6.3-15.8 hr) Drowsiness (77%) Impaired coordination (40-50%) Increased appetite (30-35%) Fatigue (30-35%) Memory impairment (30-35%) Irritability (30-35%) Decreased salivation (30-35%) Cognitive disorders (20-30%) Insomnia (20-30%) Dcreased appetite (20-30%) Headache (20-30%) Lightheadedness (20-30%) Dysarthria (20-30%) Diarrhea, constipation, and nausea/vomiting (20-30%) Weight change (20-30%) Nasal congestion (15-20%) Decreased or increased libido (10-15%) Menstrual disorder (10-15%) Difficult micturition (10-15%) Tachycardia (5-10%) Confusion (5-10%) Insomnia (5-10%) Nausea/vomiting (5-10%) Blurred vision (5-10%) Nasal congestion (5-10%) Hypotension (1-5%) Syncope (1-5%) Akathisia (1-5%) Dizziness (1-5%) Increased salivation (1-5%) Nervousness (1-5%) Tremor (1-5%) Weight change (1-5%) Gastrointestinal: Liver enzyme elevations, hepatitis, hepatic failure CNS: Hypomania, mania Immunologic: Stevens-Johnson syndrome, angioedema, peripheral edema Endocrine: Hyperprolactinemia, gynecomastia, galactorrhea Concomitant use of benzodiazepines and opioids may result in profound respiratory depression, coma, and death; administer concomitantly when there are no alternative options; limit dosages and durations to minimum required; monitor for signs and symptoms of respiratory depression and sedation 10 days) Do not stop treatment abruptly; slowly taper to discontinuation (0.5 mg q3Days) Use caution in elderly patients Use caution in debilitated patients Use caution in severe respiratory depression Use caution in patients who recently received other respiratory depressants Use caution in patients who are at risk of falls May have prolonged effects in obese patients when discontinued; use caution Not for us in acute alcohol intoxication Use with caution in patients with hepatic or renal impairment Myasthenia gravis (allowable in limited circumstances) Use caution in cases of respiratory disease (COPD), sleep apnea, renal/hepatic disease, open-angle glaucoma (questionable), depression, suicide ideation, drug abuse CNS depressant; may impair ability to perform hazardous tasks Paradoxical reactions, including hyperactive or aggressive behavior reported Cigarette smoking may decrease alprazolam concentration up to 50% Mania and hypomania episodes reported in depressed patients Pregnancy category: D Lactation: Enters breast milk/not recommended Minor tranquilizers should be avoided in first trimester of pregnancy due to increased risk of congenital malformations Maternal use shortly before delivery is associated with floppy infant syndrome (good and consistent evidence) Prenatal benzodiazepine exposure slightly increases oral cleft risk (limited or inconsistent evidence) Binds receptors at several sites within the CNS, including the limbic system and reticular formation; effects may be mediated through GABA receptor system; increase in neuronal membrane permeability to chloride ions enhances the inhibitory effects of GABA; the shift in chloride ions causes hyperpolarization (less excitability) and stabilization of the neuronal membrane The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information. Azithromycin half life Tadalafil vs sildenafil side effects Some drug interactions with Percocet can be dangerous for health. Find out which medications should not stay in the system with Percocet at the same time. zoloft names Pharmacokinetic drug interactions with oral contraceptives". Clinical Pharmacokinetics.^ "Xanax Alprazolam Drug Information Uses, Side Effects, Drug Interactions and Warnings". WebMD provides information about common drug or vitamin interactions for Xanax Oral. Wondering what the effects and dangers of Xanax and alcohol are? There should be no harm in taking caffeine when you are on Xanax, whether this be in the form of caffeine pills or a strong cup of coffee. There are many potential risks associated with mixing Xanax and alcohol (and other drugs) and in this guide we will try to uncover some of the ones you have asked us about the most, while also discussing Xanax drug tests and the use of this drug in pregnancy. In fact, people who are prescribed alprazolam also tend to consume a lot of caffeine because they find that they need to take the drug throughout the day and caffeine helps to perk them up while they do this. However, just bear in mind that caffeine and Xanax work in different ways, with one slowing the body down and the other speeding it up. It is often added to a lot of soft drinks and even to food, but you can avoid consuming too much by keeping a close eye on your coffee, coke and energy drink content, while also looking at the ingredient label of any pre workout drinks that you consume before hitting the gym. As mentioned above, large doses of stimulants do not mix well with Xanax. This drug can help to combat anxiety and to slow the heart rate down, while also keeping those racing thoughts to a minimum. Drugs like cocaine and meth, on the other hand, will do the opposite and may actually make the user feel very anxious. Taking alprazolam with opioid medications (such as codeine, hydrocodone) may increase your risk of very serious side effects, including death. To lower your risk, your doctor should have you take the smallest dose of alprazolam that works, and take it for the shortest possible time. Get medical help right away if any of these very serious side effects occur: slow/shallow breathing, unusual lightheadedness, severe drowsiness/dizziness, difficulty waking up. Show More Alprazolam is used to treat anxiety and panic disorders. It belongs to a class of medications called benzodiazepines which act on the brain and nerves (central nervous system) to produce a calming effect. It works by enhancing the effects of a certain natural chemical in the body (GABA). Read the Medication Guide provided by your pharmacist before you start taking alprazolam and each time you get a refill. If you have any questions, ask your doctor or pharmacist. Xanax drug interactions What Can Happen When You Mix Xanax Alprazolam with Other., Alprazolam - Wikipedia Levitra interactions Cheap generic celebrex Buy tretinoin cream usp 0.025 Both xanax and wellbutrin, a drug interactions could occur. I am going to interact with xanax and user ratings. Both alcohol and effects as well as well as well as withdrawal symptoms. Drug interactions with xanax – scene.sg Xanax Oral Interactions with Other Medication - WebMD Https// Medications are known to interact with Xanax. Includes lisinopril, tramadol, prednisone. valacyclovir hydrochloride May 10, 2017. Xanax is the brand name of alprazolam, a prescription drug used to treat. supplements you take, because these may interact with Xanax. Also. Benzodiazepines, including Xanax, produce extra depressant effects on the. Other possible negative drug interactions include.