All prescription NSAIDs, like CELEBREX, ibuprofen, naproxen, and meloxicam, increase the risk of heart attack or stroke that can lead to death. This may happen early in treatment and may increase with increasing doses of NSAIDs and with longer use of NSAIDs. CELEBREX should never be used right before or after a heart surgery called "coronary artery bypass graft" (CABG). Avoid taking NSAIDs after a recent heart attack, unless your healthcare provider tells you to do so. You may have an increased risk of another heart attack if you take NSAIDs after a recent heart attack. NSAID medications, like CELEBREX, cause an increased risk of bleeding, ulcers, and tears (perforation) of the esophagus, stomach, and intestines, at any time during treatment, which can occur without warning and may cause death. 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