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    Viagra originally developed for


    Some of the best inventions and discoveries in the history of civilization have been accidental. Penicillin, Teflon, radioactivity, even your favourite Coca-Cola were all chance discoveries. An accidental invention is one where scientists are trying to find a solution to problem A but chance upon a solution to problem B. This is exactly what happened in the case of mankind's dearly loved drug Viagra, that treats erectile dysfunction. In 1989, chemists at Pfizer's research centre in Kent, England, were working to find a new drug to treat hypertension and angina pectoris (chest pain due to blocked arteries). A new compound that was named Sildenafil (UK92480) was created and subsequently tested on a group of men. Unfortunately, in the clinical trials, the compound failed to have a desired effect on hypertension and did not help in dilating the muscles in the heart. cialis blog In 1953 Dr Norm Larsen, founder of the Rocket Chemical Company, was trying to create a fluid which would prevent nuclear missiles from going rusty. There’s lots of waiting around in a Cold War, and the US government found that their arsenal wasn’t faring well. A group of scientists working at Pfizer's lab in Kent developed a drug called Sildenafil for the treatment of angina. Clinical trials in Swansea found that it had almost no effect on the heart or angina, but quite a pronounced side effect on another organ. Cue a quick brainstorming session by the marketing department, and Viagra soon went on sale across the globe. In 2008, the peak sales year for the drug, Pfizer sold almost $2bn worth of the stuff. The patent has now expired in much of Europe, allowing rival companies to sell their own versions.

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    Nov 30, 2017. However, young men who use Viagra as a lifestyle drug can harm their potency, because they begin to doubt their virility without it, and develop. levitra lawsuit Oct 20, 2014. Older men like Playboy's Hugh Hefner and actor Michael Douglas have sung the praises of Viagra, but now scientists say the erectile. Aug 3, 2018. One of mankinds most dearly loved drug Viagra was an accidental discovery and one that became lifechanging for a lot of men and women.

    The primary indication of sildenafil is treatment of erectile dysfunction (inability to sustain a satisfactory erection to complete intercourse). Its use is now one of the standard treatments for erectile dysfunction, including for men with diabetes mellitus. Rare but serious adverse effects found through postmarketing surveillance include prolonged erections, severe low blood pressure, myocardial infarction (heart attack), ventricular arrhythmias, stroke, increased intraocular pressure, and sudden hearing loss. Care should be exercised by people who are also taking protease inhibitors for the treatment of HIV infection. Protease inhibitors inhibit the metabolism of sildenafil, effectively multiplying the plasma levels of sildenafil, increasing the incidence and severity of side effects. Those using protease inhibitors are recommended to limit their use of sildenafil to no more than one 25 mg dose every 48 hours. blocker (typically prescribed for hypertension or for urologic conditions, such as benign prostatic hypertrophy) at the same time may lead to low blood pressure, but this effect does not occur if they are taken at least 4 hours apart. Ten years ago this month, the Food and Drug Administration's approval of a little blue pill changed the sex lives of millions of men and women. Viagra, the first oral treatment for erectile dysfunction was developed accidentally by scientists at Pfizer Laboratories and was greenlighted for use by the FDA on March 27, 1998."Originally, we were testing sildenafil, the active drug in Viagra, as a cardiovascular drug and for its ability to lower blood pressure,'' Dr. Brian Klee, senior medical director at Pfizer, told French news agency, AFP. "But one thing that was found during those trials is that people didn't want to give the medication back because of the side effect of having erections that were harder, firmer and lasted longer.'' Since its approval, Viagra has been used by 35 million men around the world. It took the taboo out of impotence — former presidential candidate Bob Dole who suffered from erectile dysfunction after surgery for prostate cancer once appeared in a commercial for the drug — and made it easier to treat.

    Viagra originally developed for

    I Took Knockoff Viagra Until I Learned What's In It - Tonic, Viagra Performs Not Only in Bed, But in the Heart - NBC News

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  3. Jan 9, 2015. Here are six products, including Viagra and bubble wrap, which were invented. But it was originally developed as a medicine, which inventor.

    • Six products originally invented for something else - Telegraph
    • How Viagra Was Invented Accidentally -
    • Viagra protects the heart back to the future for the love pills - On.

    Mar 27, 2013. Wednesday marks the 15th anniversary of Viagra's FDA approval in the. But how did a drug that was originally tested for the treatment of heart. pet amoxicillin Jan 14, 2016. The potent passion pill was originally designed to ease physical. real last name and Peter Dunn developed a drug called sildenafil citrate. Feb 16, 2019. A look at the history, benefits, and economics of Viagra sildenafil and. The sildenafil compound was originally developed by Pfizer for the.

     
  4. Leonhard Moderator

    Being someone who is familiar with the LASIK eye surgery business, I quite honestly find it perplexing how the bait and switch marketing tactics of large chains seem to fool the public. In today’s LASIK eye surgery world, you would think that patients could understand that 0 LASIK is a myth. I guess everyone is intrigued by a low price, but do they really understand what is happening? When you start out the process with some simple searches on Google you really begin to understand how people can be confused. Depending on the market area, you will see 0 LASIK and a lot of 00 off LASIK promotions. Many credible eye care practices will not undertake this misleading marketing tactic and potential clients skip over them because their offer isn’t as enticing. It is too bad that patients have to miss out on the opportunity to work with the best surgeons in their area because of this style of marketing. Experienced LASIK Eye Surgeons in Chicago, IL QualSight LASIK buy xenical in spain Lasik for 9 is This a Scam? Doctor Answers, Tips How Much Does LASIK Cost? -
     
  5. viva2 New Member

    Amoxicillin gehört zu der Gruppe der Aminopenicilline, und ist seit 1981 auf dem deutschen Markt zugelassen. Sein Wirkspektrum erstreckt sich zwar über viele Bakterienarten (Breitbandantibiotikum), bei der Behandlung der Parodontose nutzt man vor allem seine Wirksamkeit gegenüber dem Markerkeim Aggregatibacter actinomycetemcomitans (A.a.). Sein häufiger Einsatz (Atemwegserkrankungen, Harnwegsinfeke) hat die Resistenzrate ansteigen lassen. Das von vielen Bakterien produzierte Enzym Beta-Lactamase inaktiviert Amoxicllin. de Graaff, Microbiological and Clinical Results of Metronidazole Plus Amoxicillin Therapy in Actinobacillus actinomycetemcomitans-Associated Periodontitis, Journal of Periodontology, January 1992, Vol. 1, 52-57 Die Fragen in unserem Parodontose-Selbsttest sind so gewählt, dass Sie sie entweder direkt oder mit Hilfe eines Spiegels leicht beantworten können. die Munddusche mittlerweile nicht mehr nur als Lifestyleprodukt gilt, sondern sich als gutes Hilfsmittel in der Zahnzwischenraumpflege, die bei der Parodontitisbehandlung besonders wichtig ist, etabliert hat? Zum "Schutz" gibt es aber den Beta-Lactamase-Hemmstoff Clavulansäure, der in Kombination gegeben werden kann (z. Augmentan®) und die Wirksamkeit von Amoxicillin deutlich erhöht. So können Sie sich schnell über Ihr persönliches Parodontitis-Risiko informieren. Amoxicillin wirkt bakterizid, (bakterienabtötend) indem es die Zellwandsynthese von Bakterien hemmt. Da Amoxicillin gegen die meisten anderen Parodontitisbakterien nicht ausreichend wirksam ist, erfordert deren Vorhandensein (Bakterientest) meist die Kombination mit dem Antibiotikum Metronidazol (auch "van-Winkelhoff-Cocktail" genannt). Flemmig, Münster, Gemeinsame Stellungnahme der Deutschen Gesellschaft für Zahn-, Mund- und Kieferkrankheiten(DGZMK) und der Deutschen Gesellschaft für Parodontologie (DGP). Es ist mit Ciprofloxacin das einzige wirksame Antibiotikum gegen den Parodontitis-Markerkeim Aggregatibacter actinomycetemcomitans (A.a.). Van-Winkelhoff war der Behandler, der diese Wirkstoffkombination erstmalig beschrieben hatte. AMOXIL ORAL SUSP Dosage & Rx Info Uses, Side Effects - cialis paypal accepted Amoxicillin – Wikipedia Amoxicillin Oral Route Proper Use - Mayo Clinic
     
  6. Tuman Well-Known Member

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