Global health care giant Glaxo Smith Kline LLC (GSK) agreed to plead guilty and to pay $3 billion to resolve its criminal and civil liability arising from the company’s unlawful promotion of certain prescription drugs, its failure to report certain safety data, and its civil liability for alleged false price reporting practices, the Justice Department announced today. The resolution is the largest health care fraud settlement in U. history and the largest payment ever by a drug company. GSK agreed to plead guilty to a three-count criminal information, including two counts of introducing misbranded drugs, Paxil and Wellbutrin, into interstate commerce and one count of failing to report safety data about the drug Avandia to the Food and Drug Administration (FDA). GSK will also pay $2 billion to resolve its civil liabilities with the federal government under the False Claims Act, as well as the states. Under the terms of the plea agreement, GSK will pay a total of $1 billion, including a criminal fine of $956,814,400 and forfeiture in the amount of $43,185,600. GSK’s guilty plea and sentence is not final until accepted by the U. The civil settlement resolves claims relating to Paxil, Wellbutrin and Avandia, as well as additional drugs, and also resolves pricing fraud allegations. The criminal plea agreement also includes certain non-monetary compliance commitments and certifications by GSK’s U. “Today’s multi-billion dollar settlement is unprecedented in both size and scope. 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