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Metoprolol interactions

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    Metoprolol interactions


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    Medications are known to interact with metoprolol. Includes amlodipine, prednisone, aspirin. zoloft hydrocodone A recent study revealed gender differences in the severity of interactions between metoprolol and diphenhydramine. Metoprolol is the generic form of the brand-name drug Lopressor, prescribed to treat high blood pressure and prevent angina chest pain.

    The interaction between metoprolol and bromazepam and lorazepam was studied in 12 healthy male volunteers aged 21-37 years. Metoprolol had no significant effect on the pharmacokinetics of bromazepam or lorazepam. However, bromazepam AUC was 35% higher in the presence of metoprolol. Bromazepam enhanced the effect of metoprolol on systolic blood pressure but not on diastolic blood pressure or pulse rate. Lorazepam had no effect on either blood pressure or pulse. Metoprolol did not enhance the effect of bromazepam on the psychomotor tests used in this study. Metoprolol caused a small increase in critical flicker fusion threshold with lorazepam but had no effect on the other tests. Over the years a number of studies have looked at the differences in pharmacokinetics and/or pharmacodynamics of drugs in men and women. One obvious reason for these differences is that women tend to have lower body weight than men. Adults are often given the same dose of drug regardless of body weight, so women tend to have higher serum concentrations of drugs than men. Other gender differences, such as differences in bioavailability, metabolism, and renal elimination, may also be involved. Relatively few studies, however, have looked at gender differences for drug interactions. In a recent, well-controlled study, interesting differences were found between men and women in the magnitude of the interaction between metoprolol and diphenhydramine. Metoprolol is metabolized largely by cytochrome P450 (CYP) 2D6, and diphenhydramine is a CYP2D6 inhibitor. Patients given the combination, therefore, tend to have higher metoprolol plasma concentrations and greater pharmacodynamic effects from metoprolol.

    Metoprolol interactions

    Metoprolol - CardioSmart, Effect of Gender on Drug Interactions Metoprolol- Diphenhydramine

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  5. WebMD provides information about common drug or vitamin interactions for Metoprolol Succinate Oral.

    • Metoprolol Succinate Oral Interactions with Other Medication - WebMD
    • Metoprolol Lopressor - Side Effects, Dosage, Interactions - Drugs
    • Interactions between metoprolol and antidepressants. - NCBI

    Find drug lifestyle interactions for METOPROLOL TARTRATE. metformin renal dosing Find out what painkillers you can take with metoprolol and the effect of taking other medicines alongside this beta-blocker. Overview. metoprolol. beta blocker. Interaction Characteristics CYP2D6 substrate; antihypertensive agent; bradycardia; hyperglycemia; hypoglycemia; prolongs.

     
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