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Metformin and aging

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    Metformin and aging


    Long-term treatment with the type 2 diabetes drug metformin improves health and longevity of male mice when started at middle age, reports an international team of scientists led by researchers at the National Institute on Aging (NIA), part of the National Institutes Health. The study, which tested two doses of the drug in the male mice, found the higher dose to be toxic in the animals. Scientists emphasized that considerably more research is needed before the implications of metformin for healthy aging are known for humans. D., of the NIA’s Intramural Research Program, was published in the July 30, 2013 issue of Nature Communications. “It is exciting to discover that a drug already known to be safe and effective in humans might be further studied for a possible, alternate use for healthy aging.” Prescribed since the 1960s to treat type 2 diabetes, metformin is known to enhance insulin sensitivity, prompt sugar to be converted to energy, and prevent sugar build up in the liver. “There is increasing interest in exploring how drugs for one use might be repurposed for another,” notes Richard J. It also reduces risk of health issues associated with metabolic syndrome, a condition characterized by an increased chance for heart disease and stroke, as well as type 2 diabetes. “Aging is a driving force behind metabolic syndrome and diabetes. Given that metformin is clinically proven to alleviate symptoms of these conditions, and reduce risk of cancer, we thought perhaps it was a good candidate to study for its broader effects on health and lifespan,” said de Cabo. Specifically, de Cabo’s research focuses on testing compounds that might mimic benefits of calorie restriction, as shown in some animal models. tamoxifen joint pain side effects Some exciting research from the University of Montreal has found that the drug metformin, commonly prescribed for diabetes and polycystic ovary syndrome (PCOS), has the potential to slow aging and fight cancer. The study, published in , found that metformin reduces the body's production of inflammatory cytokines, which accelerate aging. Metformin is the generic name for an oral drug that was approved by the FDA in 1994 to lower blood sugar. Brand names include Glucophage and Glucophage XR (Bristol-Myers Squibb), Fortamet (Shionogi), Glumetza and Glumetza XR (Santarus), and Riomet (Ranbaxy). Metformin was later found to stimulate ovulation, regulate periods, and increase fertility in women with PCOS and is now commonly prescribed for women whose PCOS hasn't responded to hormonal treatment alone. Found: New Potential to Slow Aging, and Slow Tumor Growth Cytokines have an important function in the body, activating the immune system to fight infection. But because they work by an inflammatory process, when they're overproduced they put the body into a state of chronic inflammation, which causes cells to age faster.

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    Medical uses. Metformin is primarily used for type 2 diabetes, but is also used in polycystic ovary syndrome. Outcomes appear to be improved even in those with some degree of kidney disease, heart failure, or liver problems. sertraline 50mg Choosing among Metformin and Clomid as effective in PCOS, so one should pay a due attention to the combination of these two powerful drugs. By James P Watson and Vince Giuliano. There is a community of self-experimenters who are taking the drug Metformin, not because they are diabetic or prediabetic, the FDA-approved reasons for prescribing the drug, but rather because they believe it probably has an impact in promoting general health and retarding aging. In fact, it is probably.

    Watch the TEDMED talk by AFAR Deputy Scientific Director Nir Barzilai, Can We Grow Older Without Getting Sicker? The entire National Geographic special, Breakthrough: The Age of Aging, spotlighting TAME and featuring AFAR experts, can be purchased on i Tunes or Amazon. Years ago I was excited about the thought of metformin being part of anti aging protocol. The latest research that I have read shows that metformin could increase chance of dementia in healthy older adults. Reply I take some supplements for their anti-aging benefits, but I would not take metformin, at least not until a lot more study is done on its benefits/drawbacks for healthy people (and those studies are not likely to be done anytime soon, as John says). I had a little test drive with metformin, took 1000mg and increased to 2000mg a day for almost 3 weeks. There are studies out there that found that Vitamin B12 deficiency is very common among metformin users, which is disturbing: https://gov/pubmed/21940283 Lots of other potential negative side effects also. My appetite went down, it felt like my stomach was fuller after meals and that my digestion was slower kind of how you feel after a heavy meal. Energy was lower when walking around and in the gym, which coincides with the lower VO2 max. I’ve tried metformin too, might have made me less hungry. The fact that all these rats studies are made with the equivalent diet of very unhealthy people makes me look at most studies with more skepticism. But I’ve only taken 500 mg at a time, and not daily. From the study on exercise and metformin, seems like one might get some benefit from metformin by taking it only sporadically and not on exercise days.

    Metformin and aging

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    Long-term treatment with the type 2 diabetes drug metformin improves health and longevity of male mice when started at middle age, reports an international. buy motilium australia Metformin, The Anti-Aging Miracle Drug. Diabetes Drugs Take A BAD RAP. by Jeffrey Dach MD. This article is part two of a series, for part one, click here. You probably think of Diabetes Drugs as all lumped together as “Bad Drugs”. Aging in humans is a well-established primary risk factor for many disabling diseases and conditions, among them diabetes, cardiovascular disease, Alzheimer's disease and cancer.

     
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