Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking chloroquine: Incidence not known Some side effects of chloroquine may occur that usually do not need medical attention. Hydroxychloroquine and peripheral neuropathy Can plaquenil cause drusen Electron microscope autoradiography was performed on the erythrocytic stages of the rodent malarial parasite, Plasmodium berghei, after exposure to 3 H-Chloroquine. 3 H-Chloroquine becomes selectively localized within the parasite food vacuoles 1 hour after it is administered, and remains in this structure for up to 24 hours. This study. Methods. Fifty‐seven patients were recruited to receive either azathioprine or chloroquine, both with prednisone, in a randomized trial. The primary end‐point was complete remission, based on normalization of aminotransferase levels in the first 6 months of treatment plus maintenance for at least 18 months, with minimal or no inflammatory activity in the liver biopsy. The saturable component of 3 Hchloroquine accumulation, measured as femtomoles of drug per 10 6 infected red blood cells, was calculated by subtracting the nonsaturable accumulation measured in the presence of 10 μM unlabeled chloroquine from the total accumulation measured in the absence of unlabeled drug. The mean + SE, calculated from. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. H-chloroquine Differential Stimulation of the Na+/H+ Exchanger Determines., Efficacy and safety of chloroquine plus prednisone for the. Is hydroxychloroquine used for fibromyalgiaPlaquenil antimalarial medications Uses of Chloroquine It is used to treat or prevent malaria. It is used to treat a type of bowel infection. It may be given to you for other reasons. Chloroquine Indications, Side Effects, Warnings -. Chloroquine Resistance in Plasmodium falciparum Malaria.. COMPARATIVE APPROACHES BETWEEN QUANTITATIVE-MSI AND.. Chloroquine is a medication used to prevent and to treat malaria in areas where malaria is known to be sensitive to its effects. Certain types of malaria, resistant strains, and complicated cases typically require different or additional medication. Chloroquine is a lysosomotropic agent as it is usually prepared as a diprotic weak base pKa 8.5. The unprotonated form of chloroquine preferentially accumulates in lysosomes as it rapidly diffuses across cell/organelle membranes. Supported in part by grants from the World Bank/UNDP/WHO Special Programme for Research and Training in Tropical Diseases. We gratefully acknowledge the contributions of Dr. Crist Filer of the New England Nuclear Corp. in the preparation of 3 Hchloroquine.