They are most common among people with weak immune systems. People with certain health conditions may need to take medications with side effects that can weaken your immune system and put you at risk for fungal infections. What is the difference between plaquenil and hydroxychloroquine What if plaquenil doesn t work A lower dose may stop them. Do not lower the dose on your own. Plaquenil stays in your body for about 3 months. If you must stop it, it will take a while for the side effects to go away. You should have an eye examination every year to prevent a very rare but serious eye problem. Plaquenil hydroxychloroquine is an antimalarial medication used to treat or prevent malaria, a disease caused by parasites, which enter the body through the bite of a mosquito. Plaquenil is also used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. This dosing would NOT apply to someone already taking plaquenil, because it has a very long ~ 30 days half-life, and it’s already in your system, so you just keep on keep’n on. This is not intended to be medical advice; this is just a reminder to refill whatever Rx for plaquenil you might already have. Fungal infections can range from mild to life-threatening. Specifically, corticosteroids and TNF (tumor necrosis factor) inhibitors are two types of medications that can increase your chances of getting a fungal infection. Does hydroxychloroquine lower your immune system RA and Hydroxychloroquine How Effective is it for Rheumatoid., Side Effects of Plaquenil Hydroxychloroquine, Warnings, Uses Chloroquine glycosylationU87 glioma chloroquine Does anyone know if Plaquenil lowers your immune system? My daughter started school in August and since then I have had one illness after another. I don't know if it's the disease itself or the medication. Or maybe it's just normal when your kid starts school. Plaquenil and lowered immune system - Sjogren's World. Having lupus, and being on plaquenil. Does that mean I.. Plaquenil and its affect on the immune system DailyStrength. Methotrexate does suppress the immune system, but serious infections with methotrexate are not common. Your rheumatologist will monitor you closely for any side effects associated with methotrexate such as liver test abnormalities, pneumonitis, or infections. Almost all autoimmune diseases require the immune system be suppressed to some degree. Hydroxychloroquine Plaquenil is the most commonly prescribed because it is generally believed to cause fewer side effects; chloroquine Aralen has a reputation for more serious side effects, but it may be prescribed in situations where hydroxychloroquine cannot be used. My Rheumatologist told me that it doesn't suppress your immune system. If you're on steroids, Methotrexate, Enbrel, or similar drugs then they will suppress your immune system. Hope this helps and best of luck! It's a tough disease but you WILL improve. It just takes time.