In a randomized, open-label, multicenter prophylaxis trial, 221 nonimmune pediatric travelers (age, 2–17 years) received either atovaquone-proguanil or chloroquine-proguanil. Safety and clinical outcome were evaluated 7, 28, and 60 days after travel. Ocular testing for plaquenil Hydroxychloroquine sulphate pregnancy Chloroquine plus proguanil is less efficacious than mefloquine, doxycycline, or AP in these areas. e Should only be used in combination with chloroquine. Indications, dose, contra-indications, side-effects, interactions, cautions, warnings and other safety information for CHLOROQUINE WITH PROGUANIL. Jul 02, 2018 Malarone atovaquone and proguanil hcl is a combination of two antimalarial medications used to treat or prevent malaria, a disease caused by parasites. Parasites that cause malaria typically enter the body through the bite of a mosquito. The data indicate that, over the course of treatment, fewer atovaquone-proguanil recipients had treatment-related adverse events (8% vs. Two subjects discontinued prophylaxis because of drug-related adverse events; both had received chloroquine-proguanil. By posttravel day 7, a total of 39 (35%) of 110 atovaquone-proguanil and 41 (37%) of 111 chloroquine-proguanil recipients reported ⩾1 adverse event. Chloroquine plus proguanil Proguanil and Chloroquine - NPA NPA, CHLOROQUINE WITH PROGUANIL Drug BNF content published. Can plaquenil cause restless leg syndrome Chloroquine plus proguanil is widely used for malaria chemoprophylaxis despite low effectiveness in areas where multidrug-resistant malaria occurs. Studies have shown that atovaquone and proguanil hydrochloride is safe and effective for prevention of falciparum malaria in lifelong residents of malaria-endemic countries, but little is known about non-immune travellers. Atovaquone-proguanil versus chloroquine-proguanil for malaria.. Side Effects of Malarone Atovaquone and Proguanil Hcl.. Chloroquine Aralen - Side Effects, Dosage, Interactions - Drugs. Patient information for CHLOROQUINE AND PROGUANIL ANTI-MALARIAL TABLETS Including dosage instructions and possible side effects. Patient information for CHLOROQUINE AND PROGUANIL ANTI-MALARIAL TABLETS Including dosage instructions and possible side effects. • You are allergic to proguanil hydrochloride, chloroquine CONCLUSION Overall mefloquine is tolerated at least as well as chloroquine plus proguanil and shows better compliance, however, symptoms related to the central nervous system are more prevalent in mefloquine users and when symptoms develop, they are perceived as more severe. Jun 15, 2004 Subsequently, 2 double-blind, controlled prophylaxis trials comparing the safety of atovaquone-proguanil with that of mefloquine and chloroquine plus proguanil hereafter, “chloroquine-proguanil” in nonimmune adults traveling to regions where malaria was endemic demonstrated that atovaquone-proguanil was associated with a lower frequency of treatment-related adverse events and of events leading to discontinuation of prophylaxis 13, 14.