There are no clear guidelines that recommend starting with one of these over the others -- and it's hit-and-miss which one will work best for any individual patient. The Dr knows exactly how your individual manifestation of the disease is presenting, what has already been tried, how you reacted to it... She choose Imuran over Methotrexate because I enjoy red wine on the weekends. So my Dr moved on to Cellcept, which was a miracle medication for me. Hydroxychloroquine cause urinary infections Hydroxychloroquine diarrhea Cutaneous hyperpigmentation during therapy with hydroxychloroquine Realistically, how long before, plaquinil, imuran, azathioprine and low dose prednisone, should control a lupus flare. I'm at 3 months starting to get discourage. ? Plaquenil is used to inhibit disease progression - most of us are started on it immediately and need to remain on it long-term. Takes 2-3 months to build up in your system. Generally a rheumy will then choose one of these three; Imuran, Cellcept, or MTX to inhibit the over-active autoimmune system that is Lupus. Learn about drug interactions between azathioprine oral and hydroxychloroquine oral and use the RxList drug interaction checker to check drug combinations. azathioprine oral brand names and other generic formulations include. Plaquenil Oral. Gram My doctor put me on 5 mg prednisone for a month while he did additional testing to confirm the lupus. All of this information goes into how s/he chooses the next course of action. I'm pondering if its just best to forget about the vino and try Methotrexate first. Azathioprine and plaquenil Plaquenil and Imuran drug interactions - eHealthMe, Treatmenmt for Lupus-Plaquenil and Imuran Hydroxychloroquine for leg crampsWeaning off of plaquenilRx hydroxychloroquine Thanks for taking the time to reply I'm taking Plaquenil for 4 years the Imuran Azathioprine spwas added during the summer. I do feel better today I did come up with the malar rash which is a sure sign that a flair is on the way but as I said I feel better today and the rash is going down. Maybe the Imuran is working. I'm taking 400mg of plaquenil and 100mg of Imuran. - LUPUS UK. Azathioprine oral and hydroxychloroquine oral Drug.. Compare Azathioprine vs Plaquenil - Comprehensive Analysis by.. Patients with rheumatoid arthritis RA, an inflammatory arthritis that can destroy joint structures, are often on multiple medications to control disease activity. These medications may have significant toxicities and side effects. Hydroxychloroquine Plaquenil is used to treat malaria, lupus, and rheumatoid arthritis. Learn about side effects, warnings, dosage, and more. Often we are given Plaquenil to inhibit progression and Prednisone steroid to treat inflammation to start with to get things under control. If our symptoms don't subside one of 3 treatments is usually prescribed - Imuran, Cellcept, MTX. Plaquenil and choose one Imuran, Cellcept, MTX are quite often used together.