I currently take 6 tablets a week and I started taking them in February this year . Has anyone been through the same as me, and find that the meds simply haven't worked so you have to simply start again. I have called my nurse specialist but she hasn't got back yet. Hang in there- it's very early days x I'm afraid Jacki08 is right it's early days and these meds take time. I am still in a lot of pain I have immense fatigue and feel miserable. I started MTX in September along with naproxen and gradually built up to 8 tablets (20mg) a week by the end of December. Chloroquine intercalating Chloroquine treatment Medication Uses How To Use Side Effects Precautions Drug Interactions Overdose Notes Missed Dose Storage. USES Hydroxychloroquine is used to prevent or treat malaria infections caused by mosquito bites. It does not work against certain types of malaria chloroquine-resistant. If after three months on the first anti-TNF biologic the patient still does not show improvement, then it is recommended to switch to another anti-TNF or a non anti-TNF. These non anti-TNFs include Orencia, Actemra, and Rituxan. If after six months there is not a positive response. May 18, 2012 The enbrel is definitely not working, and my pain level is only getting worse. My dr. suggests orencia or humira. I am interested in orencia because it is an infusion, and I do not have to deal with the hassle of injections, keeping it cold, etc. Things have been in their stride since mid February and now it's looking good regarding fatigue, swelling and pain (though I only ever had a little pain compared to what others have described). I started taking mthx in October last year and expected results quite quickly. Hydroxychloroquine not working what next Treating Lupus with Anti-Malarial Drugs Johns Hopkins Lupus., Switching Medications Without Waiting too Long RA How long does it take for plaquenil to workChloroquine: mechanism of drug action and resistance in plasmodium falciparumHydroxychloroquine sulphate side effects A lower dose may stop them. Do not lower the dose on your own. Plaquenil stays in your body for about 3 months. If you must stop it, it will take a while for the side effects to go away. You should have an eye examination every year to prevent a very rare but serious eye problem. Lupus Medicines Hydroxychloroquine - Brigham and Women's.. Enbrel not working, anyone tried orencia?. Immune & Autoimmune - Lupus Plaquenil not working anymore. Mar 17, 2016 If your overactive bladder medication isn’t working, don’t give up. Find out what other treatments you can explore. Share this article via email with one or more people using the form below. Dosage Hydroxychloroquine Plaquenil® is the drug of choice among antimalarials. Chloroquine is not commonly used because of greater toxicity on the eye. Chloroquine is not commonly used because of greater toxicity on the eye. Take hydroxychloroquine exactly as prescribed by your doctor. Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended. Hydroxychloroquine is sometimes given only once per week. Choose the same day each week to take this medicine if you are on a weekly dosing schedule.