The cramping, cold sweats, and explosive diarrhea was unimaginable. Its my classic reaction to all new psych drugs and new antiseizure drugs, including neurontin. It is a pain in the you kno what, but I have to do what I have to do! I thought I was going to pass out the pain was so bad. Plaquenil itself I've never had an issue with, but there was a med I was given for a UTI that I didn't know was NOT supposed to be with food that gave me that kind of reaction. I wasn't too bad with Plaquenil until I doubled the dose a few weeks ago to 400mg. Hydroxychloroquine retinopathy still alive and well Plaquenil and scleroderma Plaquenil immune system More energy on plaquenil Hydroxychloroquine typically is very well tolerated. Serious side effects are rare. The most common side effects are nausea and diarrhea, which often improve with time. Less common side effects include rash, changes in skin pigment such as darkening or dark spots, hair changes, and muscle weakness. Find information about common, infrequent and rare side effects of Hydroxychloroquine Oral. Nausea and diarrhea This can often can be combatted by taking Plaquenil with food or milk. If you experience stomach upset while taking generic hydroxychloroquine, ask your doctor about trying name-brand Plaquenil instead. Hopefully, it's like Lynwood said - a one time anomaly. I didn't think it was going to be like this though! I really have to shift the burden off my liver whenever I can. Love, Marji I am going on week three with the plaq and I have worked out a little routine. I did give myself a much needed cleanse though..... You might want to check the website it's a great drug interaction website that also checks some foods & seasonings Sorry you had that nasty episode, I bet it's a one-time combo of some kind that did you in. Then I had explosive diarrhea I've settled down a bit but about once a week I have a really bad blow out. But I'm starting to feel a lot better with my other symptoms, so a little digestive discomfort is worth it I suppose. Can hydroxychloroquine cause diarrhea Hydroxychloroquine - Side Effects, Dosage, Interactions., Common and Rare Side Effects for Hydroxychloroquine Oral Hydroxychloroquine autophagy inhibitorHydroxychloroquine kidney side effectsHow long does it take plaquenil to leave your systemHydroxychloroquine pka Hydroxychloroquine can cause an upset tum, it's a common side effect so it could be the longer you're taking it there's a build up effect. Trouble is you've other things coming up so it could be nervous tum, or even the two both making your tum particularly sensitive. Stomach upset or hydroxychloroquine? Good morning. - NRAS. Plaquenil What You Need to Know - Kaleidoscope Fighting Lupus. Hydroxychloroquine Pediatric Medication Memorial Sloan.. Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Aug 14, 2017 Plaquenil is the brand name of hydroxychloroquine, a drug used to prevent or treat malaria. Plaquenil is also used for long-term treatment of autoimmune diseases such as rheumatoid arthritis RA and systemic lupus erythmatosis. According to the Mayo Clinic. Aug 18, 2009 I thought that plaquenil was more processed by the kidneys than the liver and the problem you describe is what my gi doc calls "dumping" when the liver can't handle the med and acts like its poison and you get explosive diarrhea as your body tries to get rid of it.