Synthesis of chloroquine slideshare

Discussion in 'Online Canadian Pharmacy' started by quedak, 17-Mar-2020.

  1. EUGGAL User

    Synthesis of chloroquine slideshare


    Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it.

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    Chloroquine phosphate tablets should not be used in these conditions unless the benefit to the patient outweighs the potential risks. Usage in Pregnancy Usage of Chloroquine during pregnancy should be avoided except in the prophylaxis or treatment of malaria when the benefit outweighs the potential risk to the fetus. Antimalarial drugs CHLOROQUINE CQ • Rapidly acting erythrocytic schizontocide against all species of Plasmodia • Drug of choice for treating acute attacks caused by sensitive strains of P. vivax or P. falciparum • Controls most clinical attack in 1-2days with disappearance of parasite from peripheral blood in 1-3days • No effect on. Acute attack of chloroquine sensitive malaria• Tab. Chloroquine phosphate 250 mg – Contains 150 mg of base – Give 4 tablets stat, 2 tablets after 8 hours and, 1 tablet BD for 2 days• Patients who cannot take orally – 3.5 mg/kg IM every 6 hrs for 3 days• Tab primaquine 15 mg OD for 14 days in Plasmodium vivax, ovale• Primaqine.

    The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead.

    Synthesis of chloroquine slideshare

    Synthesis of New Chloroquine Derivatives as Antimalarial., Antimalarial drugs - SlideShare

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  6. CHLOROQUINE MECHANISM OF ACTION At high conc it Inhibits synthesis of DNA and RNA in the plasmodium. As it is basic drug it Increases pH of the vacules in the parasite, so prevent its utilization of erythrocyte hemoglobin. OTHER USES Amebic liver abscess as chloroquine is concentrated in the liver.

    • Anti Malarial Drugs authorSTREAM.
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    • Synthesis and antimalarial activity of new chloroquine..

    Quinoline Antimalarials Containing a Dibemethin Group Are Active against Chloroquinone-Resistant Plasmodium falciparum and Inhibit Chloroquine Transport via the P. falciparum Chloroquine-Resistance Transporter PfCRT. Journal of Medicinal Chemistry 2011, 54 19, 6956-6968. DOI 10.1021/jm2009698. Count__/__total__ Changes to YouTube’s Terms of Service A New Synthesis of Chloroquine

     
  7. composerr Moderator

    30 mg PO q Day for 14 days 30 mg PO q Day for 14 days with chloroquine or hydroxychloroquine Alternatively, for mild G6PD deficiency or as an alternative to daily regimen: 45 mg PO q Week for 8 weeks (use only after consultation with an infectious disease/tropical medicine expert) (CDC 2013) See also Dosing Considerations P. ovale maleria: 30 mg PO q Day for 14 days after departure from malaria-endemic area For use in combination with clindamycin in the treatment of P. Individual plans may vary and formulary information changes. Guidance for Using Tafenoquine for Prevention and Antirelapse. Animal Drugs @ FDA Primaquine Oral Uses, Side Effects, Interactions, Pictures.
     
  8. mscoder New Member

    Chloroquine Oral Uses, Side Effects, Interactions. Chloroquine is used to prevent or treat malaria caused by mosquito bites in countries where malaria is common. Malaria parasites can enter the body through these mosquito bites, and then live in.

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