In Sjögren’s, Plaquenil is used to treat many symptoms of Sjögren’s including fatigue, joint symptoms of arthritis and arthralgias (joint pain), dry mouth and dry eyes. Similar to its use in systemic lupus erythematosus, many clinicians feel that it is useful in reducing general Sjögren’s “disease activity.” One of the reasons that physicians feel comfortable in prescribing Plaquenil is its low risk to benefit ratio. Chloroquine prostate cancer Hydroxychloroquine and doxycycline Aralen SD-OCT scan from a 44-year-old woman with bilateral plaquenil toxicity. There is damage visible in the outer retina in a perifoveal distribution. Discontinuous bands in the peripheral outer retina can imply hydroxychloroquine toxicity or retinitis pigmentosa. Abnormalities in RPE contour can imply the presence of drusen Figure 3, page 56 or PEDs from CSC. Figure 3. OCT image demonstrating RPE abnormalities consistent with reticular pseudodrusen. Many systemic medications may cause retinal toxicity. One such commonly used medication for dermatologic and rheumatologic inflammatory conditions is hydroxychloroquine Plaquenil, a chloroquine derivative. It is used to treat many diseases including malaria, rheumatoid arthritis and systemic lupus erythematosus. As with any medication, allergic reactions including skin rashes and non-allergic reactions can occur. This means that the side effects of Plaquenil are mild and infrequent compared with its potential benefits. Retinal thinning in plaquenil toxicity oct The Risk of Retinal Toxicity with Plaquenil - Sjogren's, Retinal Physician - Appropriate Interpretation of OCT Imaging Plaquenil twitchingWhat lab needs to be monitored for hydroxychloroquine SHIRI SHULMAN, MD. H ydroxychloroquine HCQ; Plaquenil, Sanofi, Bridgewater, NJ is an antimalarial agent that is also commonly used as a treatment for a variety of rheumatologic and dermatologic conditions, such as rheumatoid arthritis and systemic lupus erythematosus. The most common side effect associated with its use is retinal toxicity. Retinal Physician - Hydroxychloroquine Maculopathy An.. Hydroxychloroquine-Induced Retinal Toxicity - American.. Retinal Physician - Retinal Toxicities Caused by Systemic.. Retinal photograph showing classic “bull’s eye” retinopathy of hydroxychloroquine toxicity, which represents atrophy of the retinal pigment epithelium. This is a relatively late change, and good screening can detect toxicity before any bull’s eye is visible. On an image segmentation analysis, selective thinning of the inner plexiform+ganglion cell layers P=0.021 was observed only in the perifoveal area of the patients in group 1 compared with that of group 2 by using the mixed-effects model analysis. Toxicity cannot be prevented by screening, so the goal is early detection of changes in visual field or spotting parafoveal thinning on OCT before changes to the retinal pigment epithelium appear,” Dr. Marmor said. “If the drug is stopped before there is RPE damage, progression and central visual loss can be prevented,” he said.