After two years of treatment, leflunomide is as safe as sulfasalazine and more effective. Leflunomide's efficacy and adverse events are similar to those of methotrexate. Otis pregnancy hydroxychloroquine Assay of chloroquine phosphate Plaquenil and magnesium Hi, I was diagnosed with RA and was put on sulfa, my rheumy tried adding mtx but i had awful side effects so am now on hydroxychloroquine and sulfa.this combination worked for anyone? just wondered how other people got on with it. Compare Leflunomide vs Methotrexate head-to-head with other drugs for uses, ratings, cost, side effects, interactions and more. Leflunomide rated 5.4/10 vs Methotrexate rated 6.7/10 in overall patient satisfaction. Background/Purpose The combination of methotrexate MTX, sulfasalazine SSZ and hydroxychloroquine HCQ triple therapy is a highly effective and well-tolerated treatment in rheumatoid arthritis RA. While MTX is the cornerstone of most successful combination therapies, not all patients are candidates for, or tolerate, MTX. Leflunomide, a disease-modifying anti-rheumatic drug DMARD. [Evidence level A, systematic review of randomized controlled trials]. Leflunomide costs significantly more than sulfasalazine and methotrexate. Combination of sulfasalazine hydroxychloroquine and leflunomide for ra Treating Rheumatoid Arthritis Combination Therapy, Leflunomide vs Methotrexate Comparison - Can you take chloroquine when pregnant Sulfasalazine works by slowing the radiographic progression damage to the joints of rheumatoid arthritis, and reducing pain and swelling. It is one of the first line treatments for moderate to severe rheumatoid arthritis, along with methotrexate and leuflunomide arava. Sulfasalazine - Medications for Rheumatoid Arthritis RA. Leflunomide, Sulfasalazine and Hydroxychloroquine for.. Anyone on Leflunomide, Hydroxychloroquine and MTX? - NRAS. If a patient is resistant to initial DMARD treatment with an agent such as methotrexate, combination DMARD treatment may be used, adding one or more conventional DMARDs leflunomide, hydroxychloroquine, sulfasalazine or a newer biologic treatment to methotrexate. The Finnish Rheumatoid Arthritis Combination Therapy trial also provides data on the benefit of combination therapy in patients with early, clinically active RA 2 years. In an open-label trial, patients were randomized to triple therapy or sulfasalazine, with or without prednisolone, for 2 years. Leflunomide is often used to treat rheumatoid arthritis alone or in combination with other DMARDs. Leflunomide blocks the formation of DNA, which is important for replicating cells, such as those in the immune system. It suppresses the immune system to reduce inflammation that causes pain and swelling in rheumatoid arthritis.