Volume of distribution of chloroquine

Discussion in 'Northwest Pharmacy' started by euginemadera, 23-Feb-2020.

  1. u4s Well-Known Member

    Volume of distribution of chloroquine


    Conceptual illustration of effect of drug distribution into tissue space on V: Consider 100 mg of a drug is added to 1 L of water in a beaker under two circumstances and the liquid is sampled for drug concentration (C). , also known as apparent volume of distribution) is the theoretical volume that would be necessary to contain the total amount of an administered drug at the same concentration that it is observed in the blood plasma.) is possible, and would indicate that the drug is highly distributed into tissue.

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    Results following a single dose of a 200 mg tablet versus i.v. infusion 155 mg, demonstrated a half-life of about 40 days and a large volume of distribution. Peak blood concentrations of. Plasma volumes of distribution up to 65,000 L for chloroquine and 44,257 L for hydroxychloroquine have been reported 71, 75, 77. Normalized by body mass, reported volumes of distribution for chloroquine have ranged from 204 to 800 L/kg depending on the sensitivity of the method of detecting chloroquine. Chloroquine diphosphate 3 mg base kg‐1 was given by constant rate intravenous injection over 10 min to 12 healthy adult male volunteers. Plasma concentrations of chloroquine and the principal met.

    Volume of distribution may be increased by kidney failure (due to fluid retention) and liver failure (due to altered body fluid and plasma protein binding). The initial volume of distribution describes blood concentrations prior to attaining the apparent volume of distribution and uses the same formula. In rough terms, drugs with a high lipid solubility (non-polar drugs), low rates of ionization, or low plasma protein binding capabilities have higher volumes of distribution than drugs which are more polar, more highly ionized or exhibit high plasma protein binding in the body's environment.

    Volume of distribution of chloroquine

    Pharmacokinetics of Hydroxychloroquine and Its Clinical Implications in., Pharmacology of Chloroquine and Hydroxychloroquine Ento Key

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  7. The drug has an apparent volume of distribution of 116-285 L/kg in healthy adults. Animal studies indicate that concn of chloroquine in liver, spleen, kidney, and lung are at least 200-700 times higher than those in plasma, and concentration of the drug in brain and spinal cord are at least 10-30 times higher than those in plasma.

    • Chloroquine phosphate C18H32ClN3O8P2 - PubChem.
    • Cardiovascular toxicity and distribution kinetics of intravenous..
    • Drug Distribution to Tissues - Clinical Pharmacology - Merck Manuals..

    Water Soluble drugs have low Vd. Eg. Gentamycin vd = 110 ml/kg 5. Lipid soluble drugs have high Vd Eg. Thiopental vd = 2300 ml/kg 6. Pathological condition. In edematous condition, water soluble drugs have high volume of distribution  8. Tissue binding. High Vd with higher tissue binding Eg. Although the high volume of distribution tells us that chloroquine distributes into compartments other than 1. - 4, and the concentration in those compartments is probably higher than the concentrations in blood, the GG data do not tell us how low the concentration in blood can be to yield a concentration of 32 microg/ml in Bb cyst infected tissue. Large volume of distribution 50 L/kg; Prolonged half life of several weeks 50% of chloroquine is excreted unchanged; Resuscitation Coma Prompt intubation and ventilation, if acidaemia exists, give sodium bicarbonate 1 – 2 mmol/Kg IV to prevent further toxicity during intubation. End goals should be a narrow QRS 100ms and a pH 7.45

     
  8. steelapple XenForo Moderator

    I have been on Plaquenil (well the generic form-- hydroxychloroquine) since October, and for the past about 2 weeks, I have been SEVERELY itchy. Plaquenil and itching - Taking Plaquenil for Rheumatoid Arthritis Hydroxychloroquine - Wikipedia
     
  9. ratibor New Member

    Applies to hydroxychloroquine: oral tablet Along with its needed effects, hydroxychloroquine (the active ingredient contained in Plaquenil) may cause some unwanted effects. Hydroxychloroquine By mouth - National Library of Medicine. Rx Side Effects New Plaquenil Guidelines and More - American. Hydroxychloroquine - Side Effects, Dosage, Interactions.
     
  10. ptl Moderator

    Side Effects of Plaquenil Hydroxychloroquine, Warnings, Uses What Is Plaquenil? Plaquenil hydroxychloroquine is an antimalarial medication used to treat or prevent malaria, a disease caused by parasites, which enter the body through the bite of a mosquito. Plaquenil is also used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. Plaquenil is available in generic form. What Are Side Effects of Plaquenil?

    Plaquenil What You Need to Know - Kaleidoscope Fighting Lupus