Deschloroquine used on chloroquine resistant parasites

Discussion in 'Northwest Pharmacy' started by Alexus007, 07-Mar-2020.

  1. lez77 XenForo Moderator

    Deschloroquine used on chloroquine resistant parasites


    Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it.

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    Plasmodium falciparum chloroquine resistance is a major cause of worldwide increases in malaria mortality and morbidity. Recent laboratory and clinical studies have associated chloroquine resistance with point mutations in the gene pfcrt. However, direct proof of a causal relationship has remained elusive and most models have posited a. Uses Chloroquine is used to prevent or treat malaria caused by mosquito bites in countries where malaria is common. Malaria parasites can enter the body through these mosquito bites, and then live. Use. Chloroquine is still the drug of choice for sensitive malaria parasites although ACTs are used increasingly. Chloroquine is therefore used widely for P. vivax, P. malariae and P. ovale, but except in a very few areas has been replaced for P. falciparum treatment. The time-honoured oral chloroquine regimen of 25 mg base/kg spread over 3 days 10, 10, 5 or 10, 5, 5, 5 mg/kg at 24-hour intervals can be condensed into 36 hours of drug administration.

    The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead.

    Deschloroquine used on chloroquine resistant parasites

    Carriage of ChloroquineResistant Parasites and Delay of., Chloroquine Oral Uses, Side Effects, Interactions, Pictures.

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  7. Nov 25, 2019 Parasites that cause malaria typically enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America, and Southern Asia. Chloroquine is used to treat and to prevent malaria. Chloroquine is also used to treat amebiasis infection caused by amoebae.

    • Chloroquine Uses, Side Effects & Warnings -.
    • Chloroquine - an overview ScienceDirect Topics.
    • WHO Model Prescribing Information Drugs Used in Parasitic Diseases..

    Chloroquine has long been used in the treatment or prevention of malaria from Plasmodium vivax, P. ovale, and P. malariae, excluding the malaria parasite Plasmodium falciparum, for it started to develop widespread resistance to it. Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. Sep 15, 2001 A number of agents of diverse chemical structures and properties selectively enhance the activity of chloroquine against chloroquine-resistant but not chloroquine-sensitive malaria parasites in vitro 37, 67–70. Better understanding of the mechanism of resistance reversal and the role of PfCRT will help in evaluating these agents and perhaps in identifying new candidate compounds for drug development. Chloroquine is used extensively in malaria endemic areas in Africa to treat the uncomplicated form of Plasmodium falciparum malaria. However, the efficiency of chloroquine has been severely impacted by the recent development of chloroquine resistant plasmodium falciparum parasites.

     
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