Malaria is common in areas such as Africa, South America, and Southern Asia. This medicine is not effective against all strains of malaria. Lysosomal inhibitor chloroquine Forgot plaquenil muscle weakness The European Medicines Agency EMA and the US Food and Drug Administration FDA are conducting investigations into certain ranitidine medicines, including some products commonly known as the brand-name drug Zantac, after they were found to contain a nitrosamine impurity called N-nitrosodimethylamine NDMA at low levels. Hydroxychloroquine Plaquenil is considered a disease-modifying anti-rheumatic drug DMARD. It can decrease the pain and swelling of arthritis. It may prevent joint damage and reduce the risk of long-term disability. Hydroxychloroquine is in a class of medications that was first used to prevent and treat malaria. Zantac and Plaquenil drug interactions by duration, gender, age Summary Drug interactions are reported among people who take Zantac and Plaquenil together. This study is created by eHealthMe based on reports of 700 people who take Zantac and Plaquenil from FDA, and is updated regularly. Taking hydroxychloroquine long-term or at high doses may cause irreversible damage to the retina of your eye. Hydroxychloroquine is also an antirheumatic medicine and is used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. Plaquenil and ranitidine Plaquenil Oral Uses, Side Effects, Interactions, Pictures., Hydroxychloroquine Plaquenil Hydroxychloroquine dmardHydroxychloroquine vs methotrexateChloroquine for cancer If you have psoriasis, chloroquine Aralen and hydroxychloroquine Plaquenil can cause problems. Other Medicines That Might Trigger a Flare. A few other drugs to discuss with your doctor include Drugs & Medications That Can Trigger Psoriasis Flare-Ups. Zantac and Plaquenil drug interactions - eHealthMe. Hydroxychloroquine Plaquenil Toxicity and Recommendations.. Hydroxychloroquine is a quinoline medicine used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America, and Southern Asia. This medicine is not effective against all strains of malaria. I've been on plaquenil for a year and a half and have had no side effects. It took about 8 months for the plaquenil to become completely effective and enable me to get off prednisone. Now I take plaquenil only and my lupus symptoms are much less severe with no advancement to organ involvement. Methotrexate can be associated with lowering of the blood counts, irritation of the lungs called pneumonitis, and liver injury. It is important to avoid drinking alcohol while taking methotrexate. Avoidance of pregnancy is essential as methotrexate can cause miscarriages and birth defects.