I've had RA for 5 years and took plaquenil for the first four years. Towards the end of that, I started having scalp rashes and lost a great deal of hair in patches. changed meds to Arava, which has caused severe skin irritation on my fingers, hands, and toes. Production of chloroquine Chloroquine phosphate for quarantine marine fish Plaquenil and chest pain Hydroxychloroquine normal dose range Plaquenil vs Methotrexate By Guest 1 post, last post over a year ago Dr Artem Agafonov answered this The Very Real Side Effects Of Modern Medications For Autoimmune Diseases, And What To Do About Them Plaquenil is one of the firs line drugs and may or may not have side effects. MTX is more of a "chemo" medication and may or may not have side effects. I would encourage you to look at quality of life issues and go slowly if you are not in a hurry to squelch all of the discomfort of RA. Dec 28, 2017 They are different treatments. Plaquenil is a maintenance drug in order to help prevent organ damage. Methotrextate is usually given for RA. I was on both for 6 years. No issues except some minor stomach nausea and was given a med for that which helped. If plaq was working for your symptoms I'd go back on it. I was taken off of Arava yesterday, and now have the choice of plaquenil or MTX. I have had no responses, so maybe I should ask all of you out there who have been on both: If you knew plaquenil kept your RA symptoms pretty well controlled, but you were losing your hair on it, would you go back to the Plaquenil, or would you do the MTX? West Girl Post Edited (West Girl) : 11/4/2010 PM (GMT-6) Was the plaquenil controlling your RA symptoms? But after losing heaps when I first went on it, I have stabalised now, I have thinner hair but it still looks fine and healthy. Hydroxychloroquine vs methotrexate Compare Plaquenil vs Chloroquine -, Methotrexate or Plaquenil? DailyStrength Chloroquine gg 260 What is Plaquenil? Plaquenil has active ingredients of hydroxychloroquine sulfate. It is often used in systemic lupus erythematosus. Check the latest outcomes from 50,877 Plaquenil users, or browse all drugs. What is Methotrexate? Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. Plaquenil vs. Methotrexate side effect and effectiveness.. Methotrexate vs. Plaquenil - Autoimmune diseases - Inspire. Treating Rheumatoid Arthritis DMARDs vs. Biologics.. Sorry to hear that you are having a lot of pain with your RA. I have lupus which mainly affects my joints and skin. I have been taking hydroxychloroquine which is the generic of plaquenil for the past three years. My rheumy recently added Imuran instead of methotrexate. Plaquenil hydroxychloroquine takes up to 3 months to begin working. Methotrexate–hydroxychloroquine combination therapy may cause lower disease activity in early RA than methotrexate monotherapy. Methotrexate monotherapy as first early RA treatment seems to lead to more treatment intensification. We aimed to compare the efficacy of methotrexate and hydroxychloroquine on refractory lichen planopilaris. Methods In a randomized clinical trial, 29 patients were randomly allocated to receive either 15 mg methotrexate/week or 200 mg hydroxychloroquine twice a day for 6 months.