At first it seemed like it helped now I feel the same as before I started taking the medicine other than the fact that none of my clothes fit and there is a lot more of me to carry around. Anyone know if I quit taking it if the weight will fall back off I started Hydroxychloroquine 2 weeks ago. One week in and I thought this may just work, except for the ‘extra itchiness’ I seemed to get every night. Plaquenil helping stomach inflammation Is hyd chloroquine static or cidal Urinary side effects of hydroxychloroquine Chloroquine uk pharmacy Quinacrine Atabrine is another alternative, but it is prescribed less often because it can sometimes cause a yellow discoloration of the skin. It is sometimes given in addition to hydroxychloroquine if the patient does not respond to Plaquenil alone. Hydroxychloroquine along with 30 mg of Prednisone worked for me within 3 months and did a great job. However I had a side reaction- hallucination, so I came off the drug. Plaquenil did not work as well for me,it took about 10 weeks before I saw some effect but again I had a reaction- my fatigue got even worse and I could not stay awake. HOW IT WORKS It is not clear why hydroxychloroquine is effective at treating autoimmune diseases. It is believed that hydroxychloroquine interferes with communication of cells in the immune system. I was prescribed this drug to ease my ra disease, I was taking 400mg per day which was to last for 3 months then reduced to 200mg. Right before I hit the two week mark, I woke up with my heart racing and continued feeling my heart flutter all day and I just felt week and tired. After msging Rheum, decided to stop taking meds to see how I feel and continue with the AIP to handle symptoms and try to work at ‘healing from inside out! Time will tell and I’m eager to see how much the AIP is helping once odd meds. Hydroxychloroquine not working Signs Your RA Treatment Isn't Working, How long did Plaquenil/Hydroxychloroquine take. Will plaquenil make my borderline personality disorder worseStop hair loss plaquenil Hydroxychloroquine or chloroquine tablets should be taken with or after food to reduce stomach upset. This drug does not work immediately. It may be weeks to months before you notice any benefit. Thus it is important that you take your medication regularly, otherwise, you may not receive any benefit at all. Hydroxychloroquine Sulfate - HBMC Rheumatology & Arthritis.. How does Plaquenil work?. Hydroxychloroquine Plaquenil -. Generally, hydroxychloroquine is given in 200 mg or 400 mg doses, once per day. Higher doses can sometimes be used, but only in adults and not for all cases. Some people tolerate this medication much better than other people, so it is important that individuals who are considering taking hydroxychloroquine talk with their doctor about the lowest necessary dose to reduce or eliminate their symptoms. A lower dose may stop them. Do not lower the dose on your own. Plaquenil stays in your body for about 3 months. If you must stop it, it will take a while for the side effects to go away. You should have an eye examination every year to prevent a very rare but serious eye problem. Hydroxychloroquine should not be taken with other drugs that could cause heart arrhythmias irregular heart rate or rhythm. Taking hydroxychloroquine with these drugs could cause dangerous.