See below for a comprehensive list of adverse effects. Applies to methotrexate: oral solution, oral tablet Other dosage forms: Oral route (Solution) Severe Toxic Reactions, Including Embryo-Fetal Toxicity Methotrexate can cause severe or fatal toxicities. Can plaquenil cause low white blood cell count Plaquenil cost at rite aid Aug 27, 2013 I saw him three weeks ago, and he encouraged me to try to taper down now that the plaquenil is helping so much. According to him, only doses lower than 3 mg per day can be considered to have zero long-term side effects, so he either wants me off the steroids completely, or to get at or below 3 mg. SIDE EFFECTS. The following adverse reactions have been identified during post-approval use of PLAQUENIL or other 4-aminoqunoline compounds. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure. I do know that plaquenil is generally considered the least invasive drug, generally prescribed as the first line of treatment. Methotrexate is the most commonly prescribed DMARD, but it does come with the chance of side-effects. I never had any side-effects of dire consequence, but many on this forum have. Methotrexate can cause embryo-fetal toxicity and fetal death. Monitor closely and modify dose or discontinue for the following toxicities: bone marrow suppression, infection, renal, gastrointestinal, hepatic, pulmonary, hypersensitivity and dermatologic. Methotrexate vs plaquenil side effects long term Major side effects of low-dose methotrexate - UpToDate, Side Effects of Plaquenil Hydroxychloroquine, Warnings, Uses Como ayuda el plaquenil es el lupus If you are using methotrexate long term, a liver biopsy is usually recommended. Methotrexate use has rarely caused serious sometimes fatal side effects, such as lung problems, lung infections Pneumocystis jiroveci pneumonia, skin reactions, diarrhea, and mouth sores ulcerative stomatitis. See also Side Effects section. METHOTREXATE - ORAL side effects, medical uses, and drug.. Methotrexate or Plaquenil? DailyStrength. Plaquenil vs. Methotrexate side effect and effectiveness.. I saw him three weeks ago, and he encouraged me to try to taper down now that the plaquenil is helping so much. According to him, only doses lower than 3 mg per day can be considered to have zero long-term side effects, so he either wants me off the steroids completely, or to get at or below 3 mg. Some side effects of methotrexate may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Re Methotrexate vs Plaquenil side effects long term and short term The MTX dose for autoimmune disease is about 1/1000 the dose they use in cancer patients. MTX also has a long clinical history, which makes it a trustworthy drug, they'll be no "surprise" side effects.