Chloroquine autophagy cancer

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    Chloroquine autophagy cancer


    Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials. A 4-aminoquinoline with antimalarial, anti-inflammatory, and potential chemosensitization and radiosensitization activities.

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    Autophagy is a homeostatic cellular recycling system that is responsible for degrading damaged or unnecessary cellular organelles and proteins. Cancer cells are thought to use autophagy as a source of energy in the unfavorable metastatic environment, and a number of clinical trials are now revealing the promising role of chloroquine, an autophagy inhibitor, as a novel antitumor drug. On the. Chloroquine enters the red blood cell by simple diffusion, inhibiting the parasite cell and digestive vacuole. Chloroquine then becomes protonated to CQ2+, as the digestive vacuole is known to be acidic pH 4.7; chloroquine then cannot leave by diffusion. Inhibition of autophagy using chloroquine or hydroxychloroquine has already shown promise in clinical trials and numerous other clinical trials are ongoing to determine the optimal tumors to treat.

    This agent may also interfere with the biosynthesis of nucleic acids. Although the mechanism is not well understood, chloroquine is shown to inhibit the parasitic enzyme heme polymerase that converts the toxic heme into non-toxic hemazoin, thereby resulting in the accumulation of toxic heme within the parasite.

    Chloroquine autophagy cancer

    Autophagy in cancer moving from understanding mechanism to., Chloroquine - Wikipedia

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  5. Jul 28, 2017 The autophagy inhibitor chloroquine overcomes the innate resistance of wild-type EGFR non-small-cell lung cancer cells to erlotinib. J. Thorac Oncol. 8, 693–702 2013.

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    Aug 19, 2014 Chloroquine is an antimalaria drug that also suppresses tumor growth and metastasis. Chloroquine neutralizes the pH of intracellular compartments, thereby disrupting the endosomal trafficking and lysosomal function. Whereas chloroquine impairs autophagy and proliferation in tumor cells, Maes et al. found that chloroquine suppressed the growth and metastasis of melanoma by acting on tumor. Chloroquine sensitizes breast cancer cells to chemotherapy independent of autophagy. Maycotte P1, Aryal S, Cummings CT, Thorburn J, Morgan MJ, Thorburn A. Chloroquine CQ is a 4-aminoquinoline drug used for the treatment of diverse diseases. Autophagy is a highly dynamic pathway and therefore steady-state measurements, such as assessment of expression CONTACT Muriel Mari [email protected] of Cell Biology, University of Groningen, University Medical Center Groningen, A. Deusinglaan 1, 9713

     
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    Selected from data included with permission and copyrighted by First Databank, Inc. Hydroxychloroquine-induced cardiomyopathy and heart. Plaquenil What You Need to Know - Kaleidoscope Fighting Lupus Hydroxychloroquine prevents congenital heart block.
     
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