Pepto bismol and plaquenil

Discussion in 'Health Canada Drug Database' started by AgentSmith, 04-Mar-2020.

  1. SeoGiant Well-Known Member

    Pepto bismol and plaquenil


    Falciparum Discontinue in 6 months if improvement is inadequate Use in patients with psoriasis may precipitate a severe attack of psoriasis; use with caution Postmarketing cases of life-threatening and fatal cardiomyopathy reported with use of hydroxychloroquine as well as of chloroquine Irreversible retinal damage observed in some patients who had received hydroxychloroquine sulfate; significant risk factors for retinal damage include daily doses of hydroxychloroquine sulfate greater than 6.5 mg/kg (5 mg/kg base) of actual body weight, durations of use greater than five years, subnormal glomerular filtration, use of some concomitant drug products such as tamoxifen citrate and concurrent macular disease Ocular examination is recommended within first year of therapy; baseline exam should include: best corrected distance visual acuity (BCVA), an automated threshold visual field (VF) of the central 10 degrees (with retesting if an abnormality is noted), and spectral domain ocular coherence tomography (SD-OCT) For individuals with significant risk factors (daily dose of hydroxychloroquine sulfate 5.0 mg/kg base of actual body weight, subnormal glomerular filtration, use of tamoxifen citrate or concurrent macular disease) monitoring should include annual examinations which include BCVA, VF and SD-OCT; for individuals without significant risk factors, annual exams can usually be deferred until five years of treatment In individuals of Asian descent, retinal toxicity may first be noticed outside macula; in patients of Asian descent, it is recommended that visual field testing be performed in central 24 degrees instead of central 10 degrees Hydroxychloroquine should be discontinued if ocular toxicity is suspected and patient should be closely observed given that retinal changes (and visual disturbances) may progress even after cessation of therapy Hepatic disease or alcoholism Glucose-6-phosphate dehydrogenase (G6PD) deficiency is associated with hemolysis and renal impairment; use with caution Dermatologic reactions to hydroxychloroquine may occur Patients are prone to dermatitis outbreaks Signs or symptoms of cardiac compromise have appeared during acute and chronic treatment; clinical monitoring for signs and symptoms of cardiomyopathy is advised, including use of appropriate diagnostic tools such as ECG to monitor patients for cardiomyopathy during therapy; if cardiotoxicity is suspected, prompt discontinuation may prevent life-threatening complications Not for administration with other drugs that have potential to prolong QT interval; hydroxychloroquine prolongs QT interval; ventricular arrhythmias and torsades de pointes reported in patients taking hydroxychloroquine Skeletal muscle myopathy or neuropathy leading to progressive weakness and atrophy of proximal muscle groups, depressed tendon reflexes, and abnormal nerve conduction, reported; muscle and nerve biopsies have been associated with curvilinear bodies and muscle fiber atrophy with vacuolar changes; assess muscle strength and deep tendon reflexes periodically in patients on long-term therapy Suicidal behavior rarely reported in patients treated with hydroxychloroquine Hematologic reactions (including aplastic anemia) and agranulocytosis may occur May exacerbate heart failure Shown to cause severe hypoglycemia including loss of consciousness that could be life threatening in patients treated with or without antidiabetic medications; warn patients about risk of hypoglycemia and associated clinical signs and symptoms; patients presenting with clinical symptoms suggestive of hypoglycemia during treatment should have their blood glucose checked and treatment reviewed as necessary A reduction in dosage may be necessary in patients with hepatic or renal disease, as well as in those taking medicines known to affect these organs Use with caution in patients with hepatic disease or alcoholism or in conjunction with known hepatotoxic drugs Consider discontinuing therapy if any severe blood disorder such as aplastic anemia, agranulocytosis, leukopenia, or thrombocytopenia, which is not attributable to the disease under treatment appears; perform periodic blood cell counts if patients are given prolonged therapy Pregnancy category: C Lactation: Drug is concentrated in breast milk (American Academy of Pediatrics committee states that it is compatible with nursing) A: Generally acceptable. Contact the applicable plan provider for the most current information. Controlled studies in pregnant women show no evidence of fetal risk. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk. Animal studies show risk and human studies not available or neither animal nor human studies done.

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    Nov 21, 2019 Drink plenty of liquids while you are taking Pepto-Bismol. Do not take more than 8 doses in one day 24 hours. Call your doctor if you still have diarrhea after 2 days of using Pepto-Bismol. This medicine can affect the results of certain medical tests. Tell any doctor who treats you that you are using Pepto-Bismol. I had tried a variety of the popular proton pump inhibitors Prilosec, Aciphex and Nexium, Pepcid, Tums and Pepto Bismol nothing worked. I drank gallons of milk and bottles of Mylanta trying to soothe the burning, choking sensation. I avoided all sorts of “acidic” foods such as oranges, tomato sauces and red wine. Compare Pepto-Bismol vs Sulfasalazine head-to-head with other drugs for uses, ratings, cost, side effects, interactions and more. Pepto-Bismol rated 7.6/10 vs Sulfasalazine rated 5.7/10 in overall patient satisfaction.

    Unknown; may impair complement-dependent antigen-antibody reactions; inhibits locomotion of neutrophils and chemotaxis of eosinophils Increases p H and interferes with lysosomal degradation of hemoglobin, which in turn interferes with digestive vacuole function Bioavailability: Rapid and complete absorption Onset: May take 4-6 months to show response; peak response takes several months (rheumatic disease) Duration: Unknown Peak plasma time: 1-3 hr Protein bound: 55% Metabolites: Desethylhydroxychloroquine, desethylchloroquine Half-life: 32-50 days Excretion: Urine (60%) The above information is provided for general informational and educational purposes only. D: Use in LIFE-THREATENING emergencies when no safer drug available.

    Pepto bismol and plaquenil

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  7. How to stop diarrhea Anti-diarrheal medications – such as loperamide Imodium and bismuth subsalicylate Pepto-Bismol and kaolin pectin suspension Kaopectate – can reduce the severity of symptoms but won’t speed recovery. They also can worsen or prolong diarrhea caused by parasites or bacteria.

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    Pepto-Bismol®, is an antacid medication used to treat temporary discomforts of the stomach and gastrointestinal tract. What did the researchers investigate? The researchers investigated whether these drugs improve the symptoms of lymphocytic colitis e.g. diarrhea or microscopic inflammation and whether any side effects result from treatment. Provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Data sources include IBM Watson Micromedex updated, Cerner Multum™ updated, Wolters Kluwer™ updated. WebMD provides information about interactions between Pepto-Bismol Oral and di-trivalent-cations-chloroquine-hydroxychloroquine.

     
  8. anvilaj Well-Known Member

    Plaquenil (hydroxychloroquine) belongs to a group of medicines called quinolines. Plaquenil From Malaria Treatment to Managing Lupus, RA. Traditional RA Disease modifying anti-rheumatic drugs Plaquenil a possible treatment for Coronovirus.
     
  9. SicilianUA Moderator

    I have been taking plaquenil for a little over 10 years and getting eye exams regularly. Hydroxychloroquine-related retinal toxicity Rheumatology. Quantitative assessment of outer retinal layers and ellipsoid. Plaquenil Retinotoxicity Updated Guidelines
     
  10. iazia User

    CHLOROQUINE Drug BNF content published by NICE Dose equivalence and conversion. Doses expressed as chloroquine base. Each tablet contains 155 mg of chloroquine base equivalent to 250 mg of chloroquine phosphate. Syrup contains 50 mg/5 mL of chloroquine base equivalent to 80 mg/5 mL of chloroquine phosphate.

    Chloroquine CHEBI3638