Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Chloroquine in chikungunya Is plaquenil safe in pregnancy Plaquenil side effect reversible or irreversible How does chloroquine work on malaria How to use Plaquenil. Lupus and/or rheumatoid arthritis patients will most likely take this medication by mouth, usually once or twice daily or as directed. Hydroxychloroquine generally is given to adults in doses of 200 mg or 400 mg per day. In some cases, higher doses can be used. Damage to the retina, the light sensitive portion of the inner eye, can occur with long-term use of Plaquenil or chloroquine Aralen. With Plaquenil, however, the most commonly prescribed anti-malarial, this sort of damage occurs only in 1 out of 5,000 people who take the drug for five years or more. Experiences taking Plaquenil for Fatigue and Muscle Pain? - Scleroderma. prairie7. December 5, 2017 at am. I definitely have more energy that I haven't had in. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. More energy on plaquenil Treatment/Plaquenil -, Treating Lupus with Anti-Malarial Drugs Johns Hopkins Lupus. Mucinex and hydroxychloroquine According to the American College of Rheumatology, hydroxychloroquine Plaquenil, is a “disease-modifying anti-rheumatic drug DMARD,” meaning that it helps reduce the pain and swelling that come with arthritis. It can also reduce the incidence of joint damage, thus lessening the risk of developing a long-term disability from. RA and Hydroxychloroquine How Effective is it for Rheumatoid.. Experiences taking Plaquenil for Fatigue and Muscle Pain.. Does Plaquenil make you tired? DailyStrength. Find information about common, infrequent and rare side effects of Plaquenil Oral. Jun 22, 2012 As you adjust to the plaquenil you will feel some energy surges. At least I did. The fatigue you're feeling is from you feeling better and trying to do more. I know it's hard, but you need to rest when the fatigue hits or you need to save up your energy to avoid the fatigue. You'll feel the full effect of the plaquenil about 3 months in. Jan 11, 2012 I hadn't really considered it, but I had to take a break from the plaquenil because of stomach issues. Thankyou all for the suggestions to restart slowly, by the way. I'm tolerating it much better. I had only been taking it for a couple weeks and I already seemed to have more energy. About a week after I stopped taking it I had a wicked flare.