Choi et al 2014 chloroquine paclitaxel

Discussion in 'Health Canada Drug Database' started by Sergey_D, 11-Mar-2020.

  1. Vedmak XenForo Moderator

    Choi et al 2014 chloroquine paclitaxel


    Detailed information on how Wiley uses cookies can be found in our Privacy Policy. Cancer stem cells (CSCs), corresponding with a poor prognosis despite systemic chemotherapy.

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    During the permeabilization of mitochondrial membrane, endonuclease G Endo G and apoptosis-inducing factor AIF translocate from mitochondria to nucleus triggering chromatin condensation and digestion of DNA in a caspase-independent manner Marino et al. 2014; Artus et al. 2010. In this study, FIP-gts and chloroquine induced mitochondrial. Chemotherapy-induced peripheral neuropathy CIPN, a consequence of peripheral nerve fiber dysfunction or degeneration, continues to be a dose-limiting and debilitating side effect during and/or after cancer chemotherapy. Paclitaxel, a taxane commonly used to treat breast, lung, and ovarian cancers, causes CIPN in 59–78% of cancer patients. Novel interventions are needed due to the current. Recently, some researches have applied GEM combined with CQ to metastatic or unresectable PC Boone, Bahary et al. 2015, Samaras, Tusup et al. 2017. The primary results showed promising safety.

    CQ was identified as a potential CSC inhibitor through in silico gene expression signature analysis of the CD44 CSC population. Chloroquine (CQ), an antimalarial drug, is a lysotropic reagent which inhibits autophagy.

    Choi et al 2014 chloroquine paclitaxel

    Chloroquine eliminates cancer stem cells through deregulation., Nicotine Prevents and Reverses Paclitaxel-Induced Mechanical.

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  7. Chloroquine is also able to target CSCs in triple-negative breast cancer by downregulating various signaling pathways, such as STAT3, resulting in a reduction of CSCs Choi, et al. 2014. The ability of chloroquine to eliminate CSCs makes it a promising candidate for combination therapy with cytotoxic agents for prevention of CSC-driven tumor.

    • Chloroquine and nanoparticle drug delivery A promising combination.
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    Volk-Draper, L. et al. Paclitaxel therapy promotes breast cancer metastasis in a TLR4-dependent manner. Cancer Res. 74, 5421–5434 2014. CAS; Article; Google Scholar Administration of chloroquine in combination with paclitaxel eliminated the cancer stem cell population in both the preclinical and clinical settings, suggesting inhibition of autophagy as a successful strategy to combat TN breast tumor reoccurrence Choi et al. 2014, Liang et al. 2016. Choi, B. Y. et al. Zinc chelation reduces traumatic brain injury-induced neurogenesis in the subgranular zone of the hippocampal dentate gyrus. A. et al. Estimation of paclitaxel.

     
  8. Igorsvv Well-Known Member

    Hydroxychloroquine is widely used in the treatment of post-Lyme arthritis. Hydroxychloroquine - Side Effects, Dosage, Interactions. Conditions that Hydroxychloroquine Oral Treats What is Hydroxychloroquine? - GoodRx
     
  9. ravilchik Moderator

    This could be a problem of the nerves that subserve that area. Coccyx Tailbone Disorders MedlinePlus Get to the Root of Leg Numbness or Tingling Plaquenil causes and treats neuropathy? - NeuroTalk Support.
     
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    Chloroquine Phosphate Prices, Coupons & Savings Tips - GoodRx CHLOROQUINE is used to treat or prevent malaria infections. It is also used to treat amebiasis. The lowest GoodRx price for the most common version of chloroquine phosphate is around .38, 84% off the average retail price of 4.50.

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  11. Timawka Well-Known Member

    The Combination of Leflunomide Arava. - Arthritis Information Apr 13, 2005 The Combination of Leflunomide Arava and Methotrexate is Safe & Efficacious for the Treatment of Rheumatoid Arthritis April 13, 2005 By Arthritis Center Methotrexate MTX, an anti-metabolite that inhibits purine pathways, has been the hallmark of standard of care for many years in the treatment of rheumatoid arthritis RA.

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