Chloroquine and hydroxychloroquine for cancer therapy

Discussion in 'Health Canada Drug Database' started by Lanas, 21-Feb-2020.

  1. LuxLinks Guest

    Chloroquine and hydroxychloroquine for cancer therapy

    Based on their findings, first study author Ciska Verbaanderd, from the University of Leuven in Belgium, and her colleagues say that the drugs “deserve further clinical investigations in several cancer types.”The review was recently published in the journal . While the United States has seen a fall in cancer death rates in recent years, the disease remains a significant burden on public health. Given that cancer is increasingly becoming resistant to existing therapies, there is a desperate need to uncover new ways to fight the disease.

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    Cesses of autophagy is a more preferable approach in cancer therapy, however, and is now under investigation 28. Chloroquine in the Kidney, the Double-Edged Sword of Autophagy The use of chloroquine in combination with other chemo-therapeutic reagents may enhance cancer treatment 8, 29, but normal cells also use autophagy to maintain. November 24. Antimalarial drugs could support existing cancer treatments in two-pronged attack Chloroquine and hydroxychloroquine could make cancer treatments more effective. ScienceDaily. Repurposing Drugs in Oncology ReDO—chloroquine and hydroxychloroquine as anti-cancer agents. Ciska Verbaanderd 1,2,3, Hannelore Maes 2, Marco B Schaaf 2, Vikas P Sukhatme 4,5, Pan Pantziarka 1,6, Vidula Sukhatme 4, Patrizia Agostinis 2 and Gauthier Bouche 1

    CQ and HCQ are medications used to prevent and treat malaria. Last year, there were more than 1.6 million new cancer cases diagnosed in the U. Verbaanderd and colleagues believe that the drugs CQ and HCQ could help in this fight.

    Chloroquine and hydroxychloroquine for cancer therapy

    Aralen chloroquine Malaria Drug Side Effects & Dosage, Antimalarial drugs could support existing cancer treatments.

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  5. Since chloroquine is an 'old' drug, repurposing it to help breast cancer patients should also be very cost effective." Hydroxychloroquine inhibits autophagy, a prosurvival process that breast cancer cells induce and that antiestrogens can stimulate. Whether interfering with this process can enhance breast cancer therapy remains unknown.

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    Chloroquine and hydroxychloroquine are drugs that are used to treat malaria, but a new review suggests that they may have another purpose treating cancer. The authors are particularly excited about the potential for chloroquine and hydroxychloroquine as the evidence suggests they make tumor cells more sensitive to cancer treatment. This phase I / II trial studies the side effects and best dose of hydroxychloroquine when given together with palbociclib and letrozole before surgery in treating participants with estrogen receptor positive, HER2 negative breast cancer. Hydroxychloroquine is a substance that decreases immune responses in the body.

  6. JULEX New Member

    Hydroxychloroquine is a quinoline medicine used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Plaquenil What You Need to Know - Kaleidoscope Fighting Lupus Does Plaquenil make you tired? DailyStrength Hydroxychloroquine Plaquenil
  7. rammed Well-Known Member

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  9. pashkin XenForo Moderator

    Hydroxychloroquine retinopathy An emerging problem. Request PDF Hydroxychloroquine retinopathy An emerging problem PurposeThe aim of this case series is to raise awareness of the emerging issue of serious retinal damage caused by the prolonged.

    Rates and Predictors of Hydroxychloroquine Retinal Toxicity in Patients.