It hasnt helped my pain from rheumatoid oh but my hair is falling out ,isnt that lovely! Besides being in pain I can look at how ugly I am now with all my hair falling its just a horrible way to feel,, specially being female to lose your hair and be in pain every day! Oxycodone er plaquenil Benlysta prednisone ldn and plaquenil for lupus Amaurosis fugax from plaquenil Nearly 2 out of 3 patients with depression do not achieve remission with selective serotonin reuptake inhibitor SSRI and serotonin-norepinephrine reuptake inhibitor SNRI monotherapy—in clinical practice, this means that a psychiatrist treating 20 patients for depression. Yes i have had bad depression and anxiety attacks plaquenil. Clonazepam given but having severe fatigue and since on max dose if plaquenil for over a year, almost lost complete sight in left eye. October 30, 2019 at pm I’ve been on plaquinil since 2009 and I can’t say I’ve had increased anxiety or depression from taking it. After taking it for three weeks, I am definitely feeling side effects anxiety, depression, bouts of crying for no particular reason, weakness, fatigue, loss of appetite, weight loss, and mild abdominal cramps. I don't feel like myself at all and my husband has definitely noticed a change in me. 😢😞Taking plaquenil gave me moderate relief from the joint pain. RA sucks and so does all the medication that they come up with ,,were guinea pigs!! Plaquenil and depression and anxiety Plaquenil and anxiety/depression? - Autoimmune diseases., Hydroxychloriquine And Depression - Lupus - Inspire What does chloroquine do to dnaIs plaquenil for pain Sickmama - so very sorry to hear about your worsening moods and depression/anxiety. I can only speak for myself and my personal experience. Plaquenil has helped me on many levels on many days. I think, for me, anyway, the depression and anxiety I often feel is due to the autoimmune issues/sjogrens. Plaquenil causing mood changes and depression?. How long does it take for plaquenil to leave your system?. Anxiety and Plaquenil Has anyone experienced mood.. Plaquenil is a first-line drug treatment meaning its the go- to med they use -the one they initially start nearly everyone on when u test positive for auto-immune & it doesn't work for everyone! I tried it for a yr w not one bit of relief. The anxiety is not a common side effect nor is the depression. Sometimes there's a cumulative effect. There's nothing in Cellcept to cause anxiety or anything else mood altering. But anxiety, depression and crying are TYPICAL of prednisone. Imuran won't cause it either. But the idea that you are sicker and NEED another medication may be depressing and worry over possible side effects can cause anxiety. Anti-depressant medications are used to treat clinical depression or pain. Depression and anxiety are present in almost half of all people who have lupus and can be caused by the disease itself, by medications used to treat the disease, or by inadequate coping mechanisms.