Mechanism of action of chloroquine in malaria treatment

Discussion in 'Generic Chloroquine' started by Konstantin8, 12-Mar-2020.

  1. CRaz Guest

    Mechanism of action of chloroquine in malaria treatment


    License: CC BY 2.5Treatment of malaria is aimed at killing the schizonts by one or more mechanisms. Resistance occurs when the parasite develops mechanisms that reduce the effects of the antimalarials or bypasses the mechanisms of the drug.

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    Chloroquine is a 4-aminoquinolone compound with a complicated and still unclear mechanism of action. It is believed to reach high concentrations in the vacuoles of the parasite, which, due to its alkaline nature, raises the internal pH. Malaria. Chloroquine has long been used in the treatment or prevention of malaria from Plasmodium vivax, P. ovale, and P. malariae, excluding the malaria parasite Plasmodium falciparum, for it started to develop widespread resistance to it. Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. Chloroquine can be prescribed for either prevention or treatment of malaria. This fact sheet provides. information about its use for the prevention of malaria infection associated with travel. Center for Global Health Division of Parasitic Diseases and Malaria. Who can take chloroquine? Chloroquine can be prescribed to adults and children of.

    Monotherapy should be avoided to prevent drug considered a superior antimalarial drug to quinine. Effects of the antimalarial drug primaquine on the dynamic structure of lipid model membranes. The American journal of tropical medicine and hygiene, 77(6 Suppl), 29–35. Resistance is a major problem in some parts of the world, e.g., Africa and Southeast Asia; therefore, newer drugs are utilized.

    Mechanism of action of chloroquine in malaria treatment

    On the molecular mechanism of chloroquine's antimalarial action, Chloroquine - Wikipedia

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  6. Mechanism of Action Chloroquine, a 4-aminoquinoline, is an anti-protozoal agent. The precise mechanism by which Chloroquine exhibits activity is not known. Chloroquine, may exert its effect against Plasmodium species by concentrating in the acid vesicles of the parasite and by inhibiting polymerization of heme. It can also inhibit certain enzymes by its interaction with DNA.

    • Chloroquine - FDA prescribing information, side effects..
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    Aralen chloroquine is an antimalarial drug used for the treatment of malaria and extraintestinal amebiasis. Common side effects are reduced hearing, tinnitus, nausea, vomiting, and diarrhea. Dosage, drug interactions, and pregnancy and breastfeeding safety are provided. Although these drugs are known to accumulate by a weak base mechanism in the acidic food vacuoles of intraerythrocytic trophozoites and thereby prevent hemoglobin degradation from occurring in that organelle, the mechanism by which their selective toxicity for lysosomes of malaria trophozoites is achieved has been subject to much discussion and argument. Apr 24, 2018 Learn about Chloroquine Mechanism of action and resistance in 2 minutes. Presenter Dr. Tanmay Mehta MD, DNB, PGDCTM

     
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  8. CAKI1 Guest

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  9. theoooolioo New Member

    Antimalarial Drug Mechanism of Action What is Chloroquine? Chloroquine is a medication used to prevent and to treat malaria in areas where malaria is known to be sensitive to its effects Treatment for malaria can be done by various drugs, in this specific.

    On the molecular mechanism of chloroquine's antimalarial action