In many cases, once the offending drug has been stopped, fading of the lesions occurs. However, the pigmentation may last a long time or become permanent. Is plaquenil a maoi Chloroquine elimination half life How long chloroquine tablets is good afternoon Microscopic examination shows yellow- to brown-colored pigment granules in macrophages and fibroblasts and among collagen fibers47, 49; the pigment granules react for iron and some of them for melanin.15, 47 In 2 cases of hydroxychloroquine-associated skin pigmentation, only melanin was identified, 51 and in another 5 cases, melanin and ferric iron 6 were observed. Blue–grey pigmentation of the skin affects up to 25% of patients taking hydroxychloroquine, especially where there has been bruising. Transverse pigmented nail bands and mucosal pigmentation have also been reported. Rashes may occur in up to 10% of patients, most commonly morbilliform or psoriasiform. Drug-induced pigmentation is not generally associated with any systemic toxicity and thus has an excellent prognosis. With some exceptions, pigmentation is usually reversible and slowly fades with discontinuation of the drug. Download PDF Many systemic medications may cause retinal toxicity. Because many drugs that induce skin pigmentation also cause photosensitivity reactions, sun protection is usually recommended. Hydroxychloroquine-induced pigmentation Hydroxychloroquine-induced hyperpigmentation A case report Request PDF, Hydroxychloroquine DermNet NZ Hydroxychloroquine retinopathy mechanism The few reports of bluish pigmentation with HCQ described resolution within a few months or did not specifiy the duration of pigmentation after discontinuation of the drug 4, 5, 6. Hydroxychloroquine is converted to an inactive metabolite in the liver and excreted in urine 25% in the active form and bile. Persistent cutaneous hyperpigmentation due to hydroxychloroquinone one.. Drug-Induced Pigmentation Background, Pathophysiology, Etiology. Hydroxychloroquine induced cutaneous pigmentation a unique pattern. Most commonly, its use can result in hyperpigmentation of the forehead, hard palate, forearms, and shins 2, 3 ; it can also cause pigmentation that appears on the cheek mucosa and nails 6, 11. The development of hydroxychloroquine-associated cutaneous dyschromia is not so rare and can present as black. Skin Hyperpigmentation with Hydroxychloroquine Hydroxychloroquine Plaquenil is a common trade name is an anti-inflammatory oral medication that is commonly used to treat many autoimmune diseases. In the hair clinic, we use it for diseases such as lichen planopilaris, frontal fibrosing alopecia, Hydroxychloroquine-induced pigmentation lesions usually begin after a few months or years of treatment. When we compared our patients with the controls, we found no significant association with the duration of HCQ treatment or with the cumulative dose of HCQ.