She suffered from Sjogren syndrome and inflammatory arthritis and was currently treated with prednisone and methotrexate. She was previously treated with hydroxychloroquine (Plaquenil) 200mg bid (6.5mg/kg) for 10 years, which was stopped one year prior to presentation. What are the side effects of taking plaquenil Plaquenil vomiting Hydroxychloroquine macrophage Plaquenil pill shape To report expanded SD-OCT findings of HCQ retinopathy that may assist the clinician in earlier diagnosis. To characterize structural changes of HCQ retinopathy with SD-OCT after drug cessation. Setting Private practice and academic institution. Patient Population Patients at New England Eye Center and Ophthalmic Consultants of Boston in Boston, MA diagnosed with HCQ retinopathy and followed. Spectral domain optical coherence tomography SD OCT images taken with different commercially available SD OCT machines demonstrate the “flying saucer” sign is consistent in different individuals with hydroxychloroquine retinopathy. A Heidelberg Spectralis SD OCT in patient 9, OD. A 57-year-old female presented to the Ophthalmology clinic at UIHC complaining bilateral central photopsias for the past two years. She suffered from Sjogren syndrome and inflammatory arthritis and was currently treated with prednisone and methotrexate. She was previously treated with hydroxychloroquine Plaquenil 200mg bid 6.5mg/kg for 10 years, which was stopped one year prior to. Review of systems: Blurred vision, halos, dry eye, dry mouth, gastroesophageal reflux, joint pain Pupils: Reactive to light in each eye from 5 mm in the dark to 2 mm in the light. Extraocular movements: Full, both eyes (OU) Confrontation visual fields: Full OU Intra-ocular pressure The optic nerves appeared healthy with a 0.3 cup-to-disc ratio. Past Ocular History: None Medical History: Sjogren syndrome and inflammatory arthritis, supraventricular tachycardia, anxiety, depression, peptic ulcer disease Medications: prednisone, methotrexate, amitriptyline, ranitidine, estradiol, tizanidine, diltiazem, Restasis Allergies: codeine, droperidol Family History: heart disease, arthritis, cancer Social History: occasional alcohol but no tobacco or intravenous drug use. Oct mac plaquenil saucer Multimodal Imaging in Plaquenil Toxicity, PDF Spectral domain optical coherence tomography as an. Chloroquine treatment for cellsWhat does chloroquine do to dnaSubstitute for hydroxychloroquineMalarial chloroquine resistance Introduction Optical coherence tomography OCT technology allows the acquisition of cross-sectional images of the retina with semihistologic resolution. It permits to define the location and nature of the changes in the retina and adjacent structures and objectively evaluates the thickness of the retina and surrounding structures. Optical Coherence Tomography in Age-related Macular.. Hydroxychloroquine Plaquenil Toxicity and.. Early Plaquenil Toxicity Detected without Bull’s Eye.. Chen E, Brown DM, Benz M, et al. Spectral domain optical coherence tomography as an effective screening test for hydroxychloroquine retinopathy the “flying saucer” sign. Clin Ophthalmol. 2010 Oct 21;51-8. Mar 15, 2019 Published March 15, 2019 Spotting the Telltale Signs of Plaquenil Toxicity Subtle but characteristic alterations on OCT are often your first clue. RO Staff This “flying saucer” may not even represent the earliest stage of HCQ toxicity visible on SD OCT, as Stepien et al described a “preclinical” stage of HCQ toxicity where the photoreceptor IS/OS junction appears “moth-eaten” due to preferential loss of cone photoreceptors.25 Even though the “flying saucer” sign was poorly visualized using time domain OCT that was also performed in all of the patients, this perifoveal loss of the photoreceptor IS/OS junction and outer retinal.