Note: based on a RGCC chemosensitivity analysis I have seen at a German clinic, Hydroxychloroquine has been effective in killing the cancer cells of 5 out 7 patients that were tested. It is one of very few available drugs that inhibits autophagy, a mechanism associated with its anticancer properties. Plaquenil and lupus rash Drug interations plaquenil Immunosuppressant plaquenil Mar 20, 2019 Pancreatic cancer cells rely on lysosome-dependent pathways, which are an essential component of autophagy, where cancer cells break down and recycle some of their own components for fuel. Following a previously published pre-clinical validation, this phase I study evaluated the safety, maximum tolerated dose, anti-tumour activity and immune status of a gemcitabine–chloroquine combination as a first- or late-line treatment in patients with metastatic or unresectable pancreatic cancer. Dr. Kimmelman and colleagues were able to display that chloroquine and its derivative, hydroxychloroquine, could block the growth of pancreatic cancer cells in a dish. Other cell types that do not depend on autophagy were unaffected by chloroquine treatment. In cancer, authophagy is the process used by cancer cells to “self-eat” in order to survive. Specifically, if authophagy is prolonged this will become a lethal process to cancer. duing chemotheraphy, radiotheraphy, etc.) authophagy is used by cancer cells to survive. However, note that Chloroquine has other properties as well that may be very well related to anti cancer mechanism, such as zinc ionophore, and others (see below the section on mechanisms). Chloroquine and pancreatic cancer Chloroquine and Cancer Treatment - Biomedical Research, A., Phase I study of a chloroquine–gemcitabine combination in. Pics of corneal chloroquine toxicitySide effects plaquenil forumsCan i take plaquenil at the same time as metformin Hydroxychloroquine is approved for the treatment of non-cancerous illnesses such as rheumatoid arthritis and systemic lupus erythematous. Researchers in the laboratory have tested tumors from patients with pancreatic cancer and have discovered that they have certain pathways inside the cells that promote growth and survival of the tumor. Hydroxychloroquine in Previously Treated Patients With.. Malaria drug could be used to treat pancreatic cancer - Pancreatic.. Chloroquine & Hydroxychloroquine supporting chemo.. Usual Adult Dose for Malaria Prophylaxis. 500 mg chloroquine phosphate 300 mg base orally on the same day each week Comments -If possible, suppressive therapy should start 2 weeks prior to exposure; if unable to start 2 weeks before exposure, an initial loading dose of 1 g chloroquine phosphate. Jul 15, 2014 Autophagy and cancer. A large body of evidence suggests that the relationship between autophagy and cancer is complex.42, 43 On the one hand, autophagy appears to inhibit malignant transformation, reflecting its capability to limit the accumulation of potentially oncogenic entities like depolarized mitochondria which overproduce potentially genotoxic reactive oxygen species, ROS. Conclusion Autophagy blockage with chloroquine or similar-acting drugs may serve as a viable therapy for highly metastatic pancreatic cancers. INTRODUCTION For the past decade the incidence of pancreatic cancer has increased by about 1.5% per year; it is currently the fourth leading cause of cancer death in the United States 1.