But Chloroquine has significantly higher rate of retinal toxicity, so it isn't used much anymore. Also, Plaquenil appears to effectively reduce flares in patients with lupus not necessarily by suppressing immunity. Read more Anxiety over potential eye problems with Hydroxychloroquine is completely unwarranted if the dose is kept below 6mg/kg (2.2lbs) of body weight. Read more See 1 more doctor answer It can cause eye problems so you need to see an ophthalmologist and peridoic screenings. Read more Results are very good, particulary when used alone and better with methotrexate. What can plaquenil treat Plaquenil cause weight gain Plaquenil vs methotrexate How does Plaquenil work? Plaquenil changes the way your immune system works. In some kinds of lupus, your immune system attacks your body instead of protecting it. Plaquenil tries to quiet or slow down the immune system. How do you take Plaquenil? You take Plaquenil as a pill 1 or 2 times a day. Take the pills with food or milk. The two types of antimalarials most often prescribed today for lupus are hydroxychloroquine Plaquenil® and chloroquine Aralen®. Unlike the rapid response seen with steroids, it may take months before antimalarial drugs improve your lupus symptoms. Anti-rheumatic drug A medication first used for malaria, hydroxychloroquine Plaquenil® is used to treat rheumatoid arthritis, some lupus symptoms, childhood arthritis and other autoimmune diseases. NSAID painkillers Nonsteroidal Anti-Inflammatory Drugs are often used for joint pain, muscle aches, headaches and tenderness. NSAIDs can be addictive in nature, form dependence, and cause side effects, including kidney damage and liver damage. Chloroquine can be substituted for Plaquenil but only in limited circumstances. Please provide more detailed information if you want a more specific answer. Read more See 1 more doctor answer Depends on what you are being treated for.... Read more While plaquenyl is a slow acting but effective drug, Prednisone is used in much higher doses in active sle. Arthritis (non-deforming) or arthralgias associated with the disease will have substantial pain relief with a dose this low. It's infusion intervals are longer, because the turnover of recptors is slower than the production of tnf-a itself. So other meds like Imuran and Cell Cept (mycophenolate mofetil) also reduce flares, but also increases infection. Read more It depends why you are taking Plaquenil in the first place. Apart from some stomach quiziies, I have never stopped this drug, as long as it demonstrated it is working. Other than that we see a few people who have increased skin pigmentation called "plaquenil ochronosis". The dirrence with Remicade (infliximab) is that it blocks the tnf-a receptor, rather than binding tnf-a itself, but it accomplishes the same thing. Lupus alternatives to plaquenil Plaquenil Compared to Alternatives -, Medications used to treat lupus Lupus Foundation of America Diphenhydramine interaction with plaquenilChloroquine pubchemLyme biaxin plaquenilPlaquenil and feeling sickScarring alopecia plaquenil or hydroxychloroquine Has anyone not been able to tolerate plaquenil hydroxychloroquine and/or chloroquine - what have been your alternatives. which is the complete opposite of my normal personality. Luckily my normal Lupus symptoms are not very advanced yet so the DR. has me on 200mg 1x daily and after about 2.5months I seem to be handling that just fine. Has anyone not been able to tolerate plaquenil.. Natural Lupus Treatment for Symptoms and Management - Dr. Axe. I am so afraid to take plaquenil for lupus treatment! any.. The treatment of systemic lupus erythematosus SLE has evolved in the last few decades owing to improved understanding of the inflammatory and immunological processes underpinning the disease. I to have been taking plaquenil for at least 6 to 8 months not sure a lil lupie lol anyway and i do feel a difference in my eyes plus my liver enzymes are up i believe that the highest is 47 and mines is 48 the doc says not dangerously high but we need to keep an eye on it. im not sure but i thought that the enzymes were up cuz of the prednisone but now ill have to ask the doc. i too want. Other than medicine, additional lupus treatments include Surgery and transplants. In severe cases, lupus can cause damage to the organs -- especially the kidneys.