These deficiencies allow heme precursors to accumulate, causing toxicity. Porphyrias are defined by the specific enzyme deficiency. Diseases treated with plaquenil Is plaquenil a mitochondrial toxin Plaquenil kidney side effects Plaquenil testing Hydroxychloroquine oral tablet is available as a brand-name drug and a generic drug. Brand name Plaquenil. Hydroxychloroquine comes only as a tablet you take by mouth. Hydroxychloroquine is used to treat malaria, lupus erythematosus, and rheumatoid arthritis. Hydroxychloroquine for the Treatment of Hidradenitis Suppurativa The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U. S. Federal Government. The elevated levels of porphyrins in the body indicate that a person is suffering from porphyria. This is a genetic disease and this means that all related members of the family must be tested for the problem as well. The disease can be acute, in which case the liver is usually. Heme, an iron-containing pigment, is an essential cofactor of numerous hemoproteins. Two major clinical manifestations occur: neurovisceral abnormalities (the acute porphyrias) and cutaneous photosensitivity (the cutaneous porphyrias). Hydroxychloroquine elevated serum porphyrin Childhood-onset porphyria cutanea tarda Successful therapy with low., Hydroxychloroquine for the Treatment of Hidradenitis Suppurativa - Full. Plaquenil toxicity and eyesPlaquenil et allergie au soleilHydroxychloroquine blood testsHydroxychloroquine and vitamin c Incomplete remissions were associated with continued estrogen, a known susceptibility factor 44 1 patient treated with hydroxychloroquine, or carisoprodol, an inducer of hepatic heme and porphyrin synthesis, 45 for chronic back pain 2 patients treated by phlebotomy. The fourth patient with HIV infection. Low-Dose Hydroxychloroquine is as Effective as Phlebotomy in.. Porphyrin Test Results, Normal Levels and Important.. Low-Dose Hydroxychloroquine Is as Effective as Phlebotomy in.. Elevated coproporphyrin excretion in the urine can occur in any hepatobiliary disorder because bile is one the routes of porphyrin excretion. Uroporphyrin may also be elevated in patients with hepatobiliary disorders. Protoporphyrin is not excreted in urine because it is water insoluble. Plaquenil Hydroxychloroquine is used to treat and prevent malaria infection, and to reduce symptoms and progression of autoimmune diseases such as lupus & others. Hydroxychloroquine 100 mg twice weekly for up to 24 months by mouth vs. phlebotomy 450 mL biweekly until target serum ferritin reached, or up to 24 months. Safety Issues-1. Side effects of phlebotomy or hydroxychloroquine, which are the same as in clinical practice. Primary Outcome Measures Time to achievement of a normal plasma total porphyrin level.