Hydroxychloroquine is available as the brand-name drug Plaquenil. Generic drugs usually cost less than the brand-name version. Hydroxychloroquine may be used as part of a combination therapy. Plaquenil and cellcept Low dose of plaquenil Sep 21, 2018 Your doctor may diagnose morphea by examining the affected skin and asking you about your signs and symptoms. He or she may take a small sample of the affected skin skin biopsy for examination in the laboratory. This may reveal changes in your skin, such as thickening of a protein collagen in the second layer of skin dermis. Plaquenil can change the pigmentation in the skin, so it would stand to reason that it can do the same with hair. I have experienced the change in pigmentation on my legs. It looks like I have a huge bruise on the back of my leg which extends from the calf to the ankle. I call it a perma-bruise. It can reduce skin problems in lupus and prevent swelling/pain in. How to use Plaquenil. unusual tiredness, unusual/sudden weight gain, hair loss/color change, mental/mood changes e. Hydroxychloroquine is used to treat lupus erythematosus and rheumatoid arthritis. It isn’t fully understood how this drug works to treat lupus erythematosus or rheumatoid arthritis. That means you may need to take it with other drugs. It treats malaria by killing the parasites that cause the disease. Plaquenil skin changes Skin Discoloration and Plaquenil - Arthritis Information, Plaquinel changes hair color?" Lupus Community - Support Group Is plaquenil a fluoroquinoloneHow does plaquenil affect the retina Most people who take Plaquenil also take other medicines for pain and stiffness. How does Plaquenil work? Plaquenil changes the way your immune system works. In some kinds of lupus, your immune system attacks your body instead of protecting it. Plaquenil tries to quiet or slow down the immune system. How do you take Plaquenil? Lupus Medicines Hydroxychloroquine - Brigham and Women's.. Plaquenil Oral Uses, Side Effects, Interactions, Pictures.. Ask the Expert Plaquenil and Sjögren’s. Vision changes/loss of vision There is a chance that retinal damage will occur while taking hydroxychloroquine Plaquenil or chloroquine Aralen. This is called known as hydroxychloroquine retinopathy. Hydroxychloroquine HCQ-associated hyperpigmentation is uncommon, with onset ranging from 3 months to 22 years following the initiation of therapy 1. A 32-year-old woman presented with a 1.5-year history of symmetric polyarthritis, positive rheumatoid factor, and anticyclic citrullinated peptide antibody, without erosive joint changes. For the Consumer Blistering, peeling, loosening of the skin. blurred vision or other vision changes. chest discomfort, pain, or tightness. cough or hoarseness. dark urine. decreased urination. defective color vision. diarrhea. difficulty breathing. difficulty seeing at night. dizziness or.