According to legend it was first brought to Europe by a Countess who had been treated with it in Peru in the 1600s. In 1820, two French chemists isolated quinine from the cinchona bark and quinine became a treatment of reference for intermittent fever throughout the world. Quinine remains an important and effective treatment for malaria today, despite sporadic observations of quinine resistance. Can plaquenil lower your immune system Plaquenil for scleroderma Plaquenil hydroxychloroquine retinopathy Need eye exam yearly using plaquenil Research by German scientists to discover a substitute for quinine led to the synthesis in 1934 of Resochin chloroquine and Sontochin 3-methyl-chloroquine. These compounds belonged to a new class of antimalarials, the four-amino quinolines. The German research went no further and the formula for Resochin was passed to a US sister company. A chloroquine dose of 600 mg base = 1,000 mg salt should be given initially, followed by 300 mg base = 500 mg salt at 6, 24, and 48 hours after the initial dose for a total chloroquine dose of 1,500 mg base =2,500 mg salt. Chloroquine 25 mg/kg over 3 days with a single dose of SP as described above. SP plus amodiaquine This combination has been shown to produce a faster rate of clinical recovery than SP and chloroquine, but is clearly inferior to artemisinin-based combinations ACTs for the treatment of malaria. These compounds belonged to a new class of antimalarials, the four-amino quinolines. Research by German scientists to discover a substitute for quinine led to the synthesis in 1934 of Resochin (chloroquine) and Sontochin (3-methyl-chloroquine). Act chloroquine Chloroquine - Wikipedia, CDC - Malaria - Diagnosis & Treatment United States. Does plaquenil cause tinnitus ACT is the recommended first line medication for the treatment of uncomplicated Plasmadium falciparum malaria, especially in areas where resistance to Chloroquine CQ and /or sulpadoxine-pyrimethamine is above 10% WHO, 2006. Is Chloroquine Better than Artemisinin Combination Therapy.. Antimalarial medication - Wikipedia. Google Actualités. Chloroquine is used to prevent or treat malaria caused by mosquito bites in countries where malaria is common. Malaria parasites can enter the body through these mosquito bites, and then live in. ACT With Chloroquine, Amodiaquine & Sulphadoxine-pyrimethamine in Pakistan The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U. S. Federal Government. Read our disclaimer for details. Chloroquine—the standard, effective drug for decades—costs about 10 U. S. cents per course of treatment for an adult. The new effective drugs— artemisinin combination therapy ACT 1 —today cost US$2.40 per course wholesale, and can be marked up to five times that amount in pharmacies in Africa.