Pigmentation can be either normal or abnormal discoloration of oral mucous membrane. The purpose of this review mainly focuses on the main oral pigmented lesions, in order to help the clinicians establish a better approach towards the patients with pigmented oral lesions and to provide thorough knowledge regarding such lesions for patient reassurance, early definitive diagnosis and prompt treatment. Plaquenil sleepy Eosinophilotaxis hydroxychloroquine Chloroquine is rapidly and almost completely absorbed from the bowel following oral administration. Peak plasma concentrations of chloroquine are reached within 4–12 hours, but it takes 4–6 weeks for plasma concentrations to stabilise; therefore, it will take 2–3 months to see a therapeutic effect. Pigmentation varies, depending on the causative drug. It can involve accumulation of melanin, deposits of the drug or one of its metabolites, synthesis of pigments under the inﬂuence of the drug or deposition of iron after damage to the dermal vessels.11 Chloroquine and other quinine derivatives are used Aug 30, 2011 Given the history of long-term chloroquine use, the top clinical working diagnosis was drug-induced oral pigmentation caused by chloroquine phosphate. To confirm this, and rule out the possibility of melanoma, a surgical evaluation was requested and the patient then underwent an incisional biopsy Fig. 2. Pigmented lesions affecting the skin were not included in our review. Relevant data concerning oral pigmented lesions, clinical features and the possibility of malignant transformation of such lesions were reviewed thoroughly from pubmed literature published in English. Chloroquine oral pigmentation Disorders of Oral Pigmentation Background, Pathophysiology., Pigmented Lesions of the Oral Cavity Review, Differential. Lysosome chloroquineHydroxychloroquine sulphate tablets rheumatoid arthritisHydroxychloroquine in chikungunya Apr 30, 2018 Perioral chloroquine pigmentation. View Media Gallery Discoloration appears most frequently in the pretibial areas of the lower extremities but can also involve the entire nail bed, nose, cheeks, forehead, ears, and oral mucosa specifically the hard palate. Drug-Induced Pigmentation Background, Pathophysiology, Etiology. Palate Hyperpigmentation Caused by Prolonged Use of the Anti.. Chloroquine Side Effects Common, Severe, Long Term -. Antimalarial drug–induced oral hyperpigmentation is uncommon and is reported to occur on the hard palate, gingiva, lips, and buccal mucosa.15, 47 In a retrospective study, pigmentation of the buccal mucosa or the hard palate was seen in 10 patients 5% using chloroquine, but none in hydroxychloroquine, 50 and there are rare case reports of. Oct 01, 2018 Chloroquine phosphate tablets, Chloroquine phosphate, USP, is a 4-aminoquinoline compound for oral administration. It is a white, odorless, bitter tasting, crystalline substance, freely soluble inwater. Hydroxychloroquine and chloroquine have been recommended by Chinese and South Korean health authorities for the treatment COVID-19. In vitro studies have demonstrated that hydroxychloroquine is more potent than chloroquine against SARS-CoV-2 with a more tolerable safety profile.