I read that the sulfa in Plaquenil is different from those in antibiotics and most people with Lupus have an allergy to Sulfa but can take Plaquenil without any problems. I can say, however, that I have not had any cross allergic reaction to other drugs sometimes associated with sulfa allergies. Whether you try Plaquenil or not is ultimately up to you and your doctor, but a lot will depend on the type and severity of reactions that you've had. Can i take prednisone and hydroxychloroquine together What heart problems are associated with plaquenil Hydroxychloroquine sulfate is a colorless crystalline solid, soluble in water to at least 20 percent; chemically the drug is 2-4-7-Chloro-4-quinolylaminopentylethylamino ethanol sulfate 11. PLAQUENIL hydroxychloroquine sulfate tablets contain 200 mg hydroxychloroquine sulfate, equivalent to 155 mg base, and are for oral administration. I have been allergic to sulfa meds for over 30 years. I have been taking plaquenil for about 8 years with no problems. However, I was givin the generic Plaquenil at first, and I did have a reaction to that - until now I didn't reliese was the same as my sulfa reaction. Someone who has a sulfa allergy can react to some medications that contain sulfa. Sulfonamide antibiotics that can cause a reaction. Antibiotics containing chemicals called sulfonamides can trigger a reaction if you have a sulfa allergy. These antibiotics include combination drugs My reaction to sulfa consisted of wheezing, but no major distress, and Plaquenil was sufficiently different from Gantrisin that my doctor felt comfortable with prescribing it. Rashes are certainly a lot less severe than respiratory reactions. Plaquenil sulfa drug Plaquenil Oral Uses, Side Effects, Interactions, Pictures., If you are allergic to sulfa drugs does this mean you can. Mechanism of action hydroxychloroquineChloroquine heme polymerase Dosage Hydroxychloroquine Plaquenil® is the drug of choice among antimalarials. Chloroquine is not commonly used because of greater toxicity on the eye. Chloroquine is not commonly used because of greater toxicity on the eye. Rheumatoid Arthritis Treatment Options Johns Hopkins.. Sulfa allergy Which medications should I avoid? - Mayo Clinic. Methotrexate, Plaquenil or Sulfasalazine Azulfidine.. Does Plaquenil Interact with other Medications? Severe Interactions. These medications are not usually taken together. Consult your healthcare professional e.g. doctor or pharmacist for more in. Hydroxychloroquine sulfate Plaquenil is not a sulfa drug. That is a misconception. However, hydroxychloroquine can be associated with serious dermatological side effects including severe rashes and exacerbation of psoriasis. Sep 02, 2009 I have been allergic to sulfa meds for over 30 years. I have been taking plaquenil for about 8 years with no problems. However, I was givin the generic Plaquenil at first, and I did have a reaction to that - until now I didn't reliese was the same as my sulfa reaction.