Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Plaquenil hypercalcemia Plaquenil hair loss Generally, dark color skin people have more melanin than light color skin people. When melanin forms deposit in the skin it causes pigmentation. There are two types of pigmentation Hyperpigmentation, and Hypopigmentation. Hyperpigmentation is a normal and harmless condition in which the skin becomes darker in color than the normal surrounding. Hyperpigmentation of the Skin Following Chloroquine Treatment 71 DISCUSSION AND CONCLUSION The aforesaid pigmentary changes of the skin al-though, could be explained by the underlying disorder or other concomitantly administered drug predniso-lone, have followed reasonable temporal sequence to One of the potential long-term side-effects of using anti-malarial medications such as hydroxychloroquine Plaquenil, chloroquine, and quinacrine is the development of dark-colored patches on the skin. They often appear brown, black, or black and blue and tend to develop on the legs, especially around the shins. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Chloroquine hyperpigmentation pictures face Hyperpigmentation Treatment, types, and causes, Hyperpigmentation of the Skin Following Chloroquine Treatment. Chloroquine brain tumorHydroxychloroquine sulfate withdrawal Hydroxychloroquine is considered safer than chloroquine during pregnancy and lactation. Hydroxychloroquine is rapidly absorbed from the gastrointestinal tract, and steady-state concentrations are reached after 4–6 weeks; 45% of hydroxychloroquine binds to plasma proteins that are deposited in tissues such as the liver, spleen, kidney, and lung. Hydroxychloroquine DermNet NZ. Hydroxychloroquine and skin darkening Hi All. - LUPUS UK. Drug-induced pigmentation of hard palate and skin due to.. Doctor-Approved Ways to Get Rid of Hyperpigmentation For Good. Sunspots, acne scars, big brown patches whatever the cause, you’ll be glad to know that unwanted speckling of your skin can usually be resolved with over-the-counter brighteners and lighteners or the professional-strength help of your dermatologist. Mar 15, 2018 "Hyperpigmentation lasts longer in darker skin types because the more melanin that is produced, the deeper it sinks into the skin and the harder it is to get rid of," says Lily Talakoub, a. A 48-year-old man with a long-standing history of systemic lupus erythematosus presented with a three-month history of mottled blue-grey hyperpigmentation on his face and on areas of previous bruising on his arms and legs Figure 11.