I've stopped Sulfa as I was experiencing a bad taste & smell, which may be caused by sulfa. After a while it wasn't as effective and I too was prescribed methotrexate alongside. I'm about to start MTX & am hoping that I wont have side effects with that! The side effects of the methotrexate for me were horrendous (chronic chest infections) and I'm now asthmatic as a result. Plaquenil effects on diarrhea What does plaquenil do to your body Plaquenil side effects on liver Drusen plaquenil Hydroxychloroquine is sometimes combined with methotrexate for additive benefits for signs and symptoms or as part of a regimen of “triple therapy” with methotrexate and sulfasalazine. Mechanism The mechanism of action of antimalarials in the treatment of patients with rheumatoid arthritis is unknown but is thought to involve changes in antigen presentation or effects on the innate immune system. Treatment of rheumatoid arthritis with methotrexate and hydroxychloroquine, methotrexate and sulfasalazine, or a combination of the three medications results of a two-year, randomized, double-blind, placebo-controlled trial. The doses of sulfasalazine and hydroxychloroquine were 500 and 200 mg twice daily, respectively, and the initial dose of methotrexate was 7.5 mg per week. The patients were evaluated three months. I had side effects from MTX, which largely wore off, but haven't had any problems with the Hydroxy or Sulpha. I refuse to take it now even if its my passport to biologic treatment. I started with MTX which worked, but not enough so the others were added in which has been better. Methotrexate hydroxychloroquine sulfasalazine Does anyone take methotrexate and hydroxychloroquine. - NRAS, Treatment of rheumatoid arthritis with methotrexate and. 200 mg of plaquenil how long to workChloroquine phosphate reef safeChloroquine resistant malaria drugs Methotrexate may be sold under. The two most commonly used antimalarials in the treatment of psoriatic arthritis are Plaquenil. Azulfidine sulfasalazine. What are Traditional DMARDs? Psoriatic-. Treatment of Rheumatoid Arthritis with Methotrexate Alone.. DMARDs Arthritis Foundation. I have been diagnosed with Limited Scleroderma. My choices are Methotrexate, Plaquenil or Sulfasalzine Azulfidine. I researched them and determined Plaquenil would be my last choice, although it was his first, because I already have lattice degeneration of the retina in both eyes and one of the potential side effects is retinal problems. A combination of methotrexate and sulfasalazine for a mean of 24 months range 20-28 months. All 4 patients experienced clinical improvement, with a reduction in the number of involved joints and in morning stiffness. In all 3 patients who had previously taken methotrexate, we were able to reduce the dosage, and the prednisone The most commonly used DMARD is methotrexate Trexall®, Rheumatrex®, Otrexup®, Resuvo®. Other DMARDs include sulfasalazine Azulfidine®, leflunomide Arava®, hydroxychloroquine Plaquenil®, Cyclosporine Neoral®, Sandimmune®, Azathioprine Imuran®, and Apremilast Otezla®.