It can decrease the pain and swelling of arthritis. It may prevent joint damage and reduce the risk of long-term disability. Oct of macular damage secondary to plaquenil toxicity Chloroquine torsades Hydroxychloroquine sulfate “Plaquenil” in treatment of rheumatoid arthritis Rheumatoid Arthritis. The action of hydroxychloroquine is cumulative and may require weeks to months to achieve the maximum therapeutic effect see CLINICAL PHARMACOLOGY. Initial adult dosage 400 mg to 600 mg 310 to 465 mg base daily, administered as a single daily dose or in two divided doses. Originally, hydroxychloroquine was used to prevent and treat malaria and was considered very effective. Now it is generally used for rheumatoid arthritis, but it has also been shown to work well for juvenile arthritis, some lupus symptoms, and other types of autoimmune conditions. Today, it is used to treat rheumatoid arthritis, some symptoms of lupus, childhood arthritis (or juvenile idiopathic arthritis) and other autoimmune diseases. Hydroxychloroquine is in a class of medications that was first used to prevent and treat malaria. Hydroxychloroquine sulfate rheumatoid arthritis Long-Term Side Effects of Plaquenil for Rheumatoid Arthritis., Plaquenil Hydroxychloroquine Uses, Dosage, Side Effects. Is there a difference between hydroxychloroquine and hydroxychloroquine sulfate Hydroxychloroquine is a disease-modifying anti-rheumatic drug DMARD approved for adults with RA. It is often given in combination with methotrexate and sulfasalazine a treatment known as triple therapy, to help slow RA disease progression for patients who do not get relief from methotrexate therapy alone. Treatments for Rheumatoid Arthritis. RA and Hydroxychloroquine How Effective is it for Rheumatoid.. PLAQUENIL® HYDROXYCHLOROQUINE SULFATE TABLETS, USP. Hydroxychloroquine sulphate in the treatment of rheumatoid arthritis a double blind comparison of two dose regimens. Research Institute of Rheumatic Diseases, Prague, Czechoslovakia. This article has been cited by other articles in PMC. BACKGROUND Hydroxychloroquine is used for the treatment of rheumatoid arthritis RA and systemic lupus erythematosus SLE. Long term studies have shown a high rate of termination of hydroxychloroquine treatment in patients with RA. Plaquenil hydroxychloroquine "Hi, I was taking the generic form of plaquenil for over 10 years for rheumatoid arthritis. It took a few weeks to see it work but what a change for the better. Less painful joints and fatigue.