If a patient is overweight, one should use the ideal body weight to assess whether the doaily dose is in the toxic range (/= 6.5 mg/kg/day). This graph shows various formulas that have been proposed for deriving ideal body weight for women, because virtually all cases of hydroxychloroquine toxicity have been female. Plaquenil and heart issues Plaquenil used for alopecia Side effects of plaquenil on eyes Chloroquine aralen side effects The most recent 2016 guidelines from the American Academy of Ophthalmology AAO recommend the dose of HCQ ≤5 mg/kg real body weight to minimize toxicity 1. According to these new guidelines, the risk of HCQ retinal toxicity is less than 1 % in the first year of therapy and less than 2 % up to 10 years of therapy. The dosage is based on body weight. 6.5 mg/kg maximum dose 400 mg should be given on the same day each week starting 2 weeks before exposure to malaria. The usual dosage works for most people who take Plaquenil, but it is possible to increase or decrease the dose based on individual needs. It's important to watch for possible side effects and toxicity. For people who weigh less than 80 kg, a lower daily dose is prescribed, up to a maximum of 5 mg/kg of body weight. For this dosage, any woman with an ideal body weight less than 135 pounds would be in the toxic dose range. The usual hydroxychloroquine dose that is prescribed is 400 mg/day. Plaquenil dose based on weight Plaquenil Use in Autoimmune Diseases, Hydroxychloroquine Side Effects, Dosage, Uses, and More Plaquenil for lupus side effectsChloroquine side effectChloroquine interactionEffect of plaquenil on free light chains SAN FRANCISCO – Hydroxychloroquine Plaquenil dosing based on actual body weight – instead of ideal weight – is appropriate for patients with systemic lupus erythematosus SLE, according to a review of 686 lupus patients at Johns Hopkins University in Baltimore. Most were dosed by actual weight, 6.5 mg/kg up to a maximum of 400 mg/day. ACR Actual-weight hydroxychloroquine dosing works in SLE.. Taking Plaquenil for Rheumatoid Arthritis. New Guidelines on Hydroxychloroquine Dosage - Where Are We.. Medscape - Indication-specific dosing for Plaquenil hydroxychloroquine sulfate, frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & lactation schedules, and cost information. All patients in the cohort were prescribed hydroxychloroquine not to exceed a dose of 6.5 mg per kilogram. The maximum daily dose prescribed is 400 mg. In those who are on hemodialysis 200 mg was prescribed after each dialysis session. In those with renal insufficiency, the dose was 200mg daily. The calculator can help guide clinicians toward a suggested weekly dosing schedule. It takes into account the patient’s weight and risk factors for Plaquenil retinopathy. With the weekly regimens, in some cases, the daily dose may exceed the 5mg/kg/day limit, but the weekly dose does not exceed 35mg/kg/week, the creators explain.