If a patient is overweight, one should use the ideal body weight to assess whether the doaily dose is in the toxic range (/= 6.5 mg/kg/day). This graph shows various formulas that have been proposed for deriving ideal body weight for women, because virtually all cases of hydroxychloroquine toxicity have been female. Interaction of plaquenil with other drugs Plaquenil from canada Although the incidence of macular toxicity is infrequent with Plaquenil use at a dosage of 200mg or 400mg q.d. its visual impact can be devastating. 2,3 The associated classic retinal toxicity is described as a bull’s eye maculopathy ring of depigmented retinal pigment epithelium that spares the foveal area. Dosing is usually much lower in children and infants depending on their body weight, usually 5 mg, calculated as base, per kilogram kg of body weight one 200 mg tablet = 155 mg base. Child. Dec 30, 2015 SAN FRANCISCO – Hydroxychloroquine Plaquenil dosing based on actual body weight – instead of ideal weight – is appropriate for patients with systemic lupus erythematosus SLE, according to a review of 686 lupus patients at Johns Hopkins University in Baltimore. Most were dosed by actual weight, 6.5 mg/kg up to a maximum of 400 mg/day. For this dosage, any woman with an ideal body weight less than 135 pounds would be in the toxic dose range. The usual hydroxychloroquine dose that is prescribed is 400 mg/day. Plaquenil dosage by weight Plaquenil Risk Calculators, Plaquenil Hydroxychloroquine - Side Effects, Dosage. Chloroquine autophagy cancerHydroxychloroquine with histoplasmosis The recommended initial dosage of hydroxychloroquine Plaquenil for the treatment of lupus erythematosus is 400 mg once or twice daily. The recommended maintenance dose range of hydroxychloroquine Plaquenil for the treatment of lupus erythematosus is 200 to 400 mg daily. Plaquenil - Side Effects, Uses, Dosage, Overdose, Pregnancy, Alcohol.. ACR Actual-weight hydroxychloroquine dosing works in SLE, up.. Ideal Body Weight for Calculating Hydroxychloroquine Dosage. Hydroxychloroquine generally is given to adults in doses of 200 mg or 400 mg per day. In some cases, higher doses can be used. Your doctor may gradually increase or decrease your dosage over time to find the right levels for your specific symptoms and needs while having the least amount of negative side effects. The plaquenil has caused a weight gain of about 20-25 pounds for me. Since I was diagnosed with MCTD a year ago, Plaquenil has been the only medication besides eye supplements, thyroid meds - been stable for years, and most recently Evoxac that I have been given. The AAO published dosing and screening recommendations for chloroquine and hydroxychloroquine in 2016, revising previous recommendations published in 2011. The current maximum daily HCQ dose recommended by the AAO is 5 mg/kg of real weight.