Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Chloroquine phosphate dosage in child Plaquenil crp These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about. If you have a cramp, these actions may provide relief Stretch and massage. Stretch the cramped muscle and gently rub it to help it relax. For a calf cramp, put your weight on your cramped leg and bend your knee slightly. If you're unable to stand, sit on the floor or in a chair with your affected leg extended. I've been taking Plaquenil 400 mg for nearly 6 mos. I didn't seem to have any problems whatsoever with it initially, other than very short term and mild cramping/diarrhea. But now I've been dealing with considerable muscle aching and pain/spasm in some new places - or at least places that haven't bothered me in quite awhile. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Discontinuing plaquenil now have muscle spasms Hydroxychloroquine Oral Route Side Effects - Mayo Clinic, Muscle cramp - Diagnosis and treatment - Mayo Clinic Plaquenil toxicity diagnosis codePlaquenil and ringing in earsDizziness on plaquenilChloroquine phosphate fishChloroquine authophagy The medications with a high risk of causing leg cramps are certain asthma medications and diuretics, but countless others can have muscle twitches and spasms as even a low-risk side effect. That said, no one should cease taking a medication without first consulting a doctor. Leading Causes Of Muscle Twitches And Spasms - HealthPrep. Plaquenil and muscle aches and pains?. Baclofen vs. Flexeril Muscle Relaxer, Pain, Side Effects.. RARE side effects. If experienced, these tend to have a Severe expression. Abnormal Liver Function Tests. Acute Liver Failure. Acute Pustular Eruptions On Skin. Bronchospasm. Decreased Blood Platelets. Decreased White Blood Cells. I have PMR, but to get me to try to taper steroids, the rheum started me on generic Plaquenil. My right thigh muscle hurts, and walking up stairs is an issue - I can do it, but it hurts. I am trying to think back to if this was an issue when I was not on the Plaquenil - I have been on it for 4-5 months now, so it's hard to remember. I have SLE, Sjogren's APS, Hemolytic Anemia, Heart disease and now the neuropathy in my right leg. It takes a really long time for the Plaquenil to kick in. It takes a really long time for the Plaquenil to kick in.