Additionally, another exception occurred while executing the custom error page for the first exception. Download PDF Many systemic medications may cause retinal toxicity. Chloroquine & Plaquenil loss of appetite Plaquenil heavy legs Provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Diagnosis Hydroxychloroquine-induced retinal toxicity Discussion. Chloroquine CQ and hydroxychloroquine Plaquenil HCQ have been used for many years, initially for the treatment of malaria but now more commonly for the treatment of inflammatory diseases such as rheumatoid arthritis and lupus 1is now considered for new disease applications in diabetes, heart disease and adjunct. Hydroxychloroquine Plaquenil, Sanofi-Aventis remains widely used in the treatment of various rheumatologic disorders. A small percentage of patients exposed to hydroxychloroquine will develop irreversible, and potentially progressive, retinal toxicity for which no effective treatment exists. It is used to treat many diseases including malaria, rheumatoid arthritis and systemic lupus erythematosus. One such commonly used medication for dermatologic and rheumatologic inflammatory conditions is hydroxychloroquine (Plaquenil), a chloroquine derivative. Plaquenil toxicity guildeline Hydroxychloroquine And Chloroquine Screening 2016 AAO., Hydroxychloroquine Plaquenil Toxicity and. Can plaquenil cause yeast infections The restyled guidelines also mandate an examination prior to the initiation of hydroxychloroquine. While the primary physician should be aware of the new guidelines a general letter to the local doctors and pharmacists would be appropriate. Step 3. Assess the patient and carefully chart document regarding Plaquenil Retinotoxicity Updated Guidelines. New Screening Guidelines for Hydroxychloroquine Toxicity. Protecting your eyesight when taking Plaquenil Lupus.. Importance Hydroxychloroquine sulfate is widely used for the long-term treatment of autoimmune conditions but can cause irreversible toxic retinopathy. Prior estimations of risk were low but were based largely on short-term users or severe retinal toxicity bull’s eye maculopathy. The classic sign of hydroxychloroquine retinopathy is bilateral “bull’s-eye” appearance of the macula due to disruption of the retinal pigmented epithelium. However, this finding occurs late in the toxicity and once it occurs the likelihood of permanent vision loss is significant so it is not useful as a screening tool. Medication Dosage Hydroxychloroquine Plaquenil is considered a disease-modifying anti-rheumatic drug DMARD. It can decrease the pain and swelling of arthritis. It may prevent joint damage and reduce the risk of long-term disability. Hydroxychloroquine is in a class of medications that was first used to prevent and treat malaria.