Synthesis of chloroquine from m-chloroaniline

Discussion in 'Canadian Pharmacies Without An Rx' started by ovadeocancila, 11-Mar-2020.

  1. Smola New Member

    Synthesis of chloroquine from m-chloroaniline


    Chloroquine phosphate is a white, odorless, crystalline powder having a bitter taste: it discolors gradually on exposure to light. The fluorescence spectrum of chloroquine phosphate obtained on a solution of 0.2 mg/ml p H 7.9 phosphate buffers using an Aminco–Bowman spectrophotofluorometer.

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    Dec 24, 2016 OH group addition in side chain at ethyl group the Hydroxy chloroquine, which is less toxic and produce the high blood levels but slightly lowers the activity Addition of alpha diethylaminocresol in place of diethyl –diamino pentane results in production of amodiaquine, which is less toxics and also less effective as compared to. Synthesis of AQ analogues. AQ analogues were synthesized as described previously 9–12. Briefly, as an example, 7-chloro-AQs were synthesized by the condensation of m-chloroaniline with ethyl ethoxymethylene malonate to produce 4,7-dichloroquinoline. The chemical name of chloroquine phosphate in chemical abstracts is found under the heading Quinoline and designated as 7-Chloro- 4-4-diethylamino-1-methylbutylamino quinoline diphosphate. Chloroquine phosphate is a white, odorless, crystalline powder having a bitter taste it discolors gradually on exposure to light.

    Chloroquine phosphate exists in two polymorphic forms giving rise to two melting ranges. Chloroquine phosphate exhibits essentially no optical activity, existing as a racemic mixture.

    Synthesis of chloroquine from m-chloroaniline

    A New Synthesis of Chloroquine Journal of the American., Aminoquinolines active against chloroquine-resistant.

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    • Synthesis of pamaquine and chloroquine - YouTube.
    • Chloroquine Phosphate - ScienceDirect.
    • Synthesis of chloroquine from 4-amino-7-chloroquinoline.

    Chloroquine-resistance malaria species. This thesis describes research targeted at the modification of lead reversed chloroquine molecules to discover new and effective moieties, as well as to improve pharmacokinetic-related properties. An especial emphasis of this project is the addition of a sulfonamide functional group to a reversed chloroquine. Chloroquine some other drugs for the treatment of malaria have been produced in the course of time 1600- 8 effective. Synthesis For the synthesis of Chloroquin 4-Hydroxy-7-chlorochinoling must initially be produced. This goes out with the reaction of 3-Chloranilin and Oxalacetic acid diethyl ester. At this reaction Chloroquine is an anti-malaria medicine that works by interfering with the growth of parasites in the red blood cells of the human body. Parasites that cause malaria typically enter the body through the bite of a mosquito.

     
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